Background In patients with sepsis the production of arachidonic acid metabolites by
cyclooxygenase increases, but the pathophysiologic role of these prostaglandins is unclear. In …

Objective. —To analyze temporal trends in acute respiratory distress syndrome (ARDS) fatality
rates since 1983 at one institution. Design. —Cohort. Setting. —Intensive care units of a …

Acute respiratory distress syndrome (ARDS) involves an intense inflammatory response in
the lungs, with accumulation of both pro- and antiinflammatory cytokines in bronchoalveolar …

To determine the relationship between airspace cytokines and cellular inflammatory
responses in patients with the acute respiratory distress syndrome (ARDS), we performed …

Background Since the early 1980s, case fatality of patients with ARDS has decreased, and
explanations are unclear Design and methods Using identical definitions of ARDS and organ …

The goal of this study was to determine the changes that occur in surfactant-associated proteins
in bronchoalveolar lavage fluid (BAL) and serum of patients at risk for ARDS and during …

Context Health-related quality of life (HRQL) is reduced in patients who survive acute respiratory
distress (ARDS), but whether this decline in HRQL is caused by ARDS or other aspects …

… Correspondence and requests for reprints should be addressed to Kenneth P.Steinberg,
MD, Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, 325 Ninth …

Little is known about neutrophil (PMN) apoptosis in the acute respiratory distress syndrome (ARDS).
We used morphologic criteria to count apoptotic PMN in bronchoalveolar lavage …

Lung surfactant is deficient in patients with acute respiratory distress syndrome (ARDS). We
performed a randomized, prospective, controlled, open-label clinical study of administration …