The current paper demonstrates that cholesterol and its hydroxylated derivative, 25-hydroxycholesterol
(25-HC), inhibit cholesterol synthesis by two different mechanisms, both involving …

Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic
therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by …

Liddle’s syndrome is an inherited form of hypertension caused by mutations that truncate the
C-terminus Of human epithelial Na+ channel (hENaC) subunits. EX-pression of truncated f3 …

Umpolung-based strategies play a significant role in organic synthesis. Particularly important
are 1,3-dithiane linchpins, which serve as convenient acyl anion equivalents. The general …

While cilia are recognized as important signaling organelles, the extent of ciliary functions
remains unknown because of difficulties in cataloguing proteins from mammalian primary cilia. …

Drosophila melanogaster has proven to be a good model for understanding the physiology
of ion channels. We identified two novel Drosophila DEG/ ENaC proteins, Pickpocket (PPK) …

Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glucose
intolerance and fatty liver disease. We recently found that ursolic acid increases skeletal …

The sleep disorder narcolepsy is linked to the HLA-DQB1*0602 haplotype and dysregulation
of the hypocretin ligand-hypocretin receptor pathway. Narcolepsy was associated with …

Autophagy is a process delivering cytoplasmic components to lysosomes for degradation.
Autophagy may, however, play a role in unconventional secretion of leaderless cytosolic …

Approximately one-third of global CO 2 fixation is performed by eukaryotic algae. Nearly all
algae enhance their carbon assimilation by operating a CO 2 -concentrating mechanism (…