Objective assessment of adherence to inhalers by patients with chronic obstructive pulmonary disease

…, D Seow, F Rawat, E MacHale, M Mokoka… - American journal of …, 2017 - atsjournals.org
Rationale: Objective adherence to inhaled therapy by patients with chronic obstructive
pulmonary disease (COPD) has not been reported. Objectives: To objectively quantify adherence …

A randomised clinical trial of feedback on inhaler adherence and technique in patients with severe uncontrolled asthma

…, E MacHale, J Seheult, M Mokoka… - European …, 2018 - Eur Respiratory Soc
In severe asthma, poor control could reflect issues of medication adherence or inhaler technique,
or that the condition is refractory. This study aimed to determine if an intervention with (…

Personalized biofeedback on inhaler adherence and technique by community pharmacists: a cluster randomized clinical trial

…, F Boland, S Bosnic-Anticevich, MC Mokoka… - The Journal of Allergy …, 2020 - Elsevier
Background Guidelines recommend that patients treated with inhalers receive adherence
counseling and device training. Digital technologies that assess both inhaler adherence and …

A method to calculate adherence to inhaled therapy that reflects the changes in clinical features of asthma

…, V Rapcan, S D'Arcy, B Cushen, M Mokoka… - Annals of the …, 2016 - atsjournals.org
Rationale: Currently, studies on adherence to inhaled medications report average adherence
over time. This measure does not account for variations in the interval between doses, nor …

Hiatal hernias are correlated with increased severity of non‐cystic fibrosis bronchiectasis

…, M Ahmed, J Das, C Ward, M Mokoka… - …, 2015 - Wiley Online Library
Background and objective Hiatal hernias ( HH ) are associated with gastro‐oesophageal
reflux and may contribute to lung disease severity. We aimed to evaluate the prevalence of HH …

The clinical impact of different adherence behaviors in patients with severe chronic obstructive pulmonary disease

…, G Greene, E MacHale, M Mokoka… - American journal of …, 2018 - atsjournals.org
Methods This prospective, observational cohort study recruited hospitalized patients with
known COPD who had already been prescribed a salmeterol/fluticasone propionate Diskus …

[HTML][HTML] Personalising adherence-enhancing interventions using a smart inhaler in patients with COPD: an exploratory cost-effectiveness analysis

…, G Greene, E MacHale, MC Mokoka… - NPJ primary care …, 2018 - nature.com
Four inhaler adherence clusters have been identified using the INCA audio device in COPD
patients: (1) regular use/good technique, (2) regular use/frequent technique errors, (3) …

Inadequate assessment of adherence to maintenance medication leads to loss of power and increased costs in trials of severe asthma therapy: results from a …

MC Mokoka, MJ McDonnell, E MacHale… - European …, 2019 - Eur Respiratory Soc
Adherence to inhaled maintenance therapy in severe asthma is rarely adequately assessed,
and its influence on trial outcomes is unknown. We systematically determined how …

The impact of common inhaler errors on drug delivery: investigating critical errors with a dry powder inhaler

…, S Giannoutsos, B Cushen, MC Mokoka… - Journal of aerosol …, 2017 - liebertpub.com
Background: Researchers, using checklists, have identified that 30%–90% of patients make
errors in inhaler use. It is not certain whether these errors affect the delivery of medication. …

In patients with severe uncontrolled asthma, does knowledge of adherence and inhaler technique using electronic monitoring improve clinical decision making? A …

MC Mokoka, L Lombard, EM MacHale, J Walsh… - BMJ open, 2017 - bmjopen.bmj.com
Introduction Many patients with asthma remain poorly controlled despite the use of inhaled
corticosteroids and long-acting beta agonists. Poor control may arise from inadequate …