[HTML][HTML] Ethical considerations about artificial intelligence for prognostication in intensive care

M Beil, I Proft, D Van Heerden, S Sviri… - Intensive Care Medicine …, 2019 - Springer
Background Prognosticating the course of diseases to inform decision-making is a key
component of intensive care medicine. For several applications in medicine, new methods from …

Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells

M Beil, A Micoulet, G Von Wichert, S Paschke… - Nature cell …, 2003 - nature.com
Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive lipid that is present in
high density lipoproteins (HDL) particles and found at increased levels in blood and …

[HTML][HTML] Detection and segmentation of cell nuclei in virtual microscopy images: a minimum-model approach

S Wienert, D Heim, K Saeger, A Stenzinger, M Beil… - Scientific reports, 2012 - nature.com
Automated image analysis of cells and tissues has been an active research field in medical
informatics for decades but has recently attracted increased attention due to developments in …

[HTML][HTML] The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study

…, B Bollen Pinto, JC Schefold, G Wolff, M Kelm, M Beil… - Critical care, 2021 - Springer
Background The COVID-19 pandemic has led highly developed healthcare systems to the
brink of collapse due to the large numbers of patients being admitted into hospitals. One of …

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia

R Windoffer, M Beil, TM Magin, RE Leube - Journal of Cell Biology, 2011 - rupress.org
Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are abundant
in epithelia and form cytoskeletal networks that contribute to cell type–specific functions, …

[HTML][HTML] Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe

…, B Bollen Pinto, JC Schefold, G Wolff, M Kelm, M Beil… - Critical care, 2021 - Springer
Background The primary aim of this study was to assess the outcome of elderly intensive
care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. …

Critical review: cellular mechanobiology and amoeboid migration

…, F Lautenschläger, S Paschke, M Beil - Integrative biology, 2010 - academic.oup.com
Cell motility is important for tissue homeostasis and plays a central role in various pathologies,
notably inflammation and cancer. Research into the critical processes involved in cell …

The regulatory role of cell mechanics for migration of differentiating myeloid cells

…, S Schinkinger, A Bruel, M Beil… - Proceedings of the …, 2009 - National Acad Sciences
Migration of cells is important for tissue maintenance, immune response, and often altered
in disease. While biochemical aspects, including cell adhesion, have been studied in detail, …

[HTML][HTML] Expression of the highly conserved RNA binding protein KOC in embryogenesis

…, B Pohl, M Wilda, U Lacher, M Beil… - Mechanisms of …, 1999 - Elsevier
The human KOC gene which is highly expressed in cancer shows typical structural features
of an RNA binding protein. We analyzed the temporal and spatial expression pattern of KOC …

Small-molecule WNK inhibition regulates cardiovascular and renal function

…, K DiPetrillo, EJ Whalen, A Anisowicz, M Beil… - Nature chemical …, 2016 - nature.com
The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and
body fluid and electrolyte homeostasis. Herein, we introduce the first orally bioavailable pan-…