We conducted a serological study to define correlates of immunity against SARS-CoV-2.
Compared to those with mild coronavirus disease 2019 (COVID-19) cases, individuals with …

Rationale: CC16 (club cell secretory protein-16), a member of the secretoglobin family, is
one of the most abundant proteins in normal airway secretions and has been described as a …

We conducted an extensive serological study to quantify population-level exposure and
define correlates of immunity against SARS-CoV-2. We found that relative to mild COVID-19 …

Inhaled long-acting β-adrenergic agonists (LABAs) and short-acting β-adrenergic agonists
are approved for the treatment of obstructive lung disease via actions mediated by β2 …

SARS-CoV-2, the cause of COVID19, has caused a pandemic that has infected more than
80 M and killed more than 1.6 M persons worldwide. In the US as of December 2020, it has …

Background Risk assessment in pulmonary arterial hypertension (PAH) is essential for
prognostication. However, the majority of patients end-up in an intermediate risk status, offering …

Background Experimental studies demonstrate beneficial immunological and hemodynamic
effects of estradiol in animal models of sepsis. This raises the question whether estradiol …

Studies have shown that club cell secretory protein (CC16) plays important protective roles
in the lungs, yet its complete biological functions are unclear. We devised a translational …

Background Multiparametric risk assessment is used in pulmonary arterial hypertension (PAH)
to target therapy. However, this strategy is imperfect because most patients remain at …

Background Quantifying right ventricular (RV) function is important to describe the pathophysiology
of in pulmonary hypertension (PH). Current phenotyping strategies in PH rely on few …