Rationale: Using microarray data, we previously identified gene expression–based subclasses
of septic shock with important phenotypic differences. The subclass-defining genes …

… Author links open overlay panel Michael T. Bigham MD a , Rick Amato RT b , Pattie Bondurrant
RN b , Jon Fridriksson MD b , Catherine D. Krawczeski MD c , Jenni Raake RT c , Sue …

Introduction The intrinsic heterogeneity of clinical septic shock is a major challenge. For clinical
trials, individual patient management, and quality improvement efforts, it is unclear which …

The practice of pediatric/neonatal interfacility transport continues to expand. Transport teams
have evolved into mobile ICUs capable of delivering state-of-the-art critical care during …

Rationale: Interventional clinical trials involving children with septic shock would benefit from
an efficient preenrollment stratification strategy. Objectives: To test the predictive value of …

Septic shock is a frequent and costly problem among patients in the pediatric intensive care
unit (PICU) and is associated with high mortality and devastating survivor morbidity. Genome…

Objective: Septic shock heterogeneity has important implications for clinical trial implementation
and patient management. We previously addressed this heterogeneity by identifying …

Objectives: Prognostic and predictive enrichment strategies are fundamental tools of precision
medicine. Identifying children with septic shock who may benefit from corticosteroids …

Objective: The Pediatric Sepsis Biomarker Risk Model (PERSEVERE), a pediatric sepsis
risk model, uses biomarkers to estimate baseline mortality risk for pediatric septic shock. It is …

Introduction Differentiating between sterile inflammation and bacterial infection in critically ill
patients with fever and other signs of the systemic inflammatory response syndrome (SIRS) …