The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock
2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis and …

AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis
accounts for more than 50% of the cases of AKI , with a mortality rate of up to 40%. The …

Acute kidney injury (AKI) is a common complication following cardiac surgery performed on
cardiopulmonary bypass (CPB) and has important implications for prognosis. The aetiology …

Renal medullary hypoxia may contribute to cardiac surgery–associated acute kidney injury (AKI).
However, the effects of cardiopulmonary bypass (CPB) on medullary oxygenation are …

Background Global and intra-renal perfusion and oxygenation may be affected by the choice
of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on …

Background Tracheostomy is commonly performed in critically ill patients because of its clinical
advantages over prolonged translaryngeal endotracheal intubation. Early tracheostomy …

Objectives: To examine the effects of fluid bolus therapy on systemic hemodynamics, renal
blood flow, intrarenal perfusion and oxygenation, P o 2, renal function, and fluid balance in …

Background Metabolic acidosis is a major complication of critical illness. However, its current
epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis …

Norepinephrine exacerbates renal medullary hypoxia in experimental septic acute kidney
injury. Here we examined whether dexmedetomidine, an α2-adrenergic agonist, can restore …

Background Extracorporeal membrane oxygenation (ECMO) is an integral method of life
support in critically ill patients with severe cardiopulmonary failure; however, such patients …