[HTML][HTML] Observational study of hydroxychloroquine in hospitalized patients with Covid-19
…, A Labella, DK Manson, C Kubin, RG Barr… - … England Journal of …, 2020 - Mass Medical Soc
Background Hydroxychloroquine has been widely administered to patients with Covid-19
without robust evidence supporting its use. Methods We examined the association between …
without robust evidence supporting its use. Methods We examined the association between …
[HTML][HTML] Percent emphysema, airflow obstruction, and impaired left ventricular filling
RG Barr, DA Bluemke, FS Ahmed, JJ Carr… - … England Journal of …, 2010 - Mass Medical Soc
Background Very severe chronic obstructive pulmonary disease causes cor pulmonale with
elevated pulmonary vascular resistance and secondary reductions in left ventricular filling, …
elevated pulmonary vascular resistance and secondary reductions in left ventricular filling, …
Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series
Objective To characterize patients with coronavirus disease 2019 (covid-19) in a large New
York City medical center and describe their clinical course across the emergency department…
York City medical center and describe their clinical course across the emergency department…
Association between long-term exposure to ambient air pollution and change in quantitatively assessed emphysema and lung function
…, AV Diez-Roux, S Vedal, JD Kaufman, RG Barr - Jama, 2019 - jamanetwork.com
Importance While air pollutants at historical levels have been associated with cardiovascular
and respiratory diseases, it is not known whether exposure to contemporary air pollutant …
and respiratory diseases, it is not known whether exposure to contemporary air pollutant …
[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
[HTML][HTML] The clinical features of the overlap between COPD and asthma
M Hardin, EK Silverman, RG Barr, NN Hansel… - Respiratory …, 2011 - Springer
Background The coexistence of COPD and asthma is widely recognized but has not been
well described. This study characterizes clinical features, spirometry, and chest CT scans of …
well described. This study characterizes clinical features, spirometry, and chest CT scans of …
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
…, N Franceschini, YMTA Van Durme, T Chen, RG Barr… - Nature …, 2010 - nature.com
Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …
[HTML][HTML] Clinical significance of symptoms in smokers with preserved pulmonary function
PG Woodruff, RG Barr, E Bleecker… - … England Journal of …, 2016 - Mass Medical Soc
Background Currently, the diagnosis of chronic obstructive pulmonary disease (COPD)
requires a ratio of forced expiratory volume in 1 second (FEV 1 ) to forced vital capacity (FVC) of …
requires a ratio of forced expiratory volume in 1 second (FEV 1 ) to forced vital capacity (FVC) of …
[HTML][HTML] Genetic diversity fuels gene discovery for tobacco and alcohol use
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide
deaths, respectively, due largely to broad increased risk for disease and injury 1 , 2 , 3 – …
deaths, respectively, due largely to broad increased risk for disease and injury 1 , 2 , 3 – …
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
…, WOC Cookson, J Altmüller, W Ang, RG Barr… - Nature …, 2018 - nature.com
We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …