[HTML][HTML] Observational study of hydroxychloroquine in hospitalized patients with Covid-19

…, A Labella, DK Manson, C Kubin, RG Barr… - … England Journal of …, 2020 - Mass Medical Soc
Background Hydroxychloroquine has been widely administered to patients with Covid-19
without robust evidence supporting its use. Methods We examined the association between …

[HTML][HTML] Percent emphysema, airflow obstruction, and impaired left ventricular filling

RG Barr, DA Bluemke, FS Ahmed, JJ Carr… - … England Journal of …, 2010 - Mass Medical Soc
Background Very severe chronic obstructive pulmonary disease causes cor pulmonale with
elevated pulmonary vascular resistance and secondary reductions in left ventricular filling, …

Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series

…, SL Bruce, CL Slater, JR Tiao, MR Baldwin, RG Barr… - bmj, 2020 - bmj.com
Objective To characterize patients with coronavirus disease 2019 (covid-19) in a large New
York City medical center and describe their clinical course across the emergency department…

Association between long-term exposure to ambient air pollution and change in quantitatively assessed emphysema and lung function

…, AV Diez-Roux, S Vedal, JD Kaufman, RG Barr - Jama, 2019 - jamanetwork.com
Importance While air pollutants at historical levels have been associated with cardiovascular
and respiratory diseases, it is not known whether exposure to contemporary air pollutant …

[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

…, DE Arking, S Aslibekyan, PL Auer, J Barnard, RG Barr… - Nature, 2021 - nature.com
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

[HTML][HTML] The clinical features of the overlap between COPD and asthma

M Hardin, EK Silverman, RG Barr, NN Hansel… - Respiratory …, 2011 - Springer
Background The coexistence of COPD and asthma is widely recognized but has not been
well described. This study characterizes clinical features, spirometry, and chest CT scans of …

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

…, N Franceschini, YMTA Van Durme, T Chen, RG Barr… - Nature …, 2010 - nature.com
Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …

[HTML][HTML] Clinical significance of symptoms in smokers with preserved pulmonary function

PG Woodruff, RG Barr, E Bleecker… - … England Journal of …, 2016 - Mass Medical Soc
Background Currently, the diagnosis of chronic obstructive pulmonary disease (COPD)
requires a ratio of forced expiratory volume in 1 second (FEV 1 ) to forced vital capacity (FVC) of …

[HTML][HTML] Genetic diversity fuels gene discovery for tobacco and alcohol use

…, J Ma, R Mägi, A Manichaikul, NG Martin, R Mathur… - Nature, 2022 - nature.com
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide
deaths, respectively, due largely to broad increased risk for disease and injury 1 , 2 , 3 – …

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

…, WOC Cookson, J Altmüller, W Ang, RG Barr… - Nature …, 2018 - nature.com
We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …