We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n
= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

Background A range of public health measures have been implemented to suppress local
transmission of coronavirus disease 2019 (COVID-19) in Hong Kong. We examined the effect …

Some individuals with autism spectrum disorder (ASD) carry functional mutations rarely
observed in the general population. We explored the genes disrupted by these variants from …

Many respiratory viral infections such as influenza and measles result in severe acute
respiratory symptoms and epidemics. In the spring of 2003, an epidemic of coronavirus …

Background The burden of rare diseases is important for healthcare planning but difficult to
estimate. This has been facilitated by the development of ORPHAcodes, a comprehensive …

There is a worldwide belief that the prevalence of asthma and other allergic diseases is
increasing but the measures used in many studies are susceptible to systematic errors. We …

Background Macrocephaly, which is defined as a head circumference greater than or equal
to + 2 standard deviations, is a feature commonly observed in children with developmental …

BACKGROUND: Sleep problems may have different influences on students' academic
performance. We investigated the prevalence of sleep patterns, naps, and sleep disorders, and …

Objective Childhood obesity may be related to school environment, but previous studies often
focused on food environment only. This study aimed to examine the relationship between …

Background: There is a paucity of data on the prevalence, natural history and management
of food allergy in most of the populous Asian countries, including China Objective: To …