[HTML][HTML] Manipulation of host cholesterol by obligate intracellular bacteria
Cholesterol is a multifunctional lipid that plays important metabolic and structural roles in
the eukaryotic cell. Despite having diverse lifestyles, the obligate intracellular bacterial …
the eukaryotic cell. Despite having diverse lifestyles, the obligate intracellular bacterial …
[HTML][HTML] Coxiella burnetii Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth
Upon host cell infection, the obligate intracellular bacterium Coxiella burnetii resides and
multiplies within the Coxiella–Containing Vacuole (CCV). The nascent CCV progresses …
multiplies within the Coxiella–Containing Vacuole (CCV). The nascent CCV progresses …
[HTML][HTML] A Recombinant Protein Based on Trypanosoma cruzi P21 Enhances Phagocytosis
AA Rodrigues, TM Clemente, MA Dos Santos… - Plos one, 2012 - journals.plos.org
Background P21 is a secreted protein expressed in all developmental stages of Trypanosoma
cruzi. The aim of this study was to determine the effect of the recombinant protein based …
cruzi. The aim of this study was to determine the effect of the recombinant protein based …
Coxiella burnetii blocks intracellular interleukin-17 signaling in macrophages
TM Clemente, M Mulye, AV Justis… - Infection and …, 2018 - Am Soc Microbiol
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever.
Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which …
Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which …
[HTML][HTML] Establishing the intracellular niche of obligate intracellular vacuolar pathogens
Obligate intracellular pathogens occupy one of two niches – free in the host cell cytoplasm
or confined in a membrane-bound vacuole. Pathogens occupying membrane-bound …
or confined in a membrane-bound vacuole. Pathogens occupying membrane-bound …
[HTML][HTML] Coxiella burnetii actively blocks IL-17-induced oxidative stress in macrophages
Coxiella burnetii is a highly infectious pathogen that causes Q fever, a leading cause of
culture-negative endocarditis. Coxiella first targets alveolar macrophages and forms a …
culture-negative endocarditis. Coxiella first targets alveolar macrophages and forms a …
Coxiella burnetii sterol-modifying protein Stmp1 regulates cholesterol in the intracellular niche
Coxiella burnetii replicates in a phagolysosome-like vacuole called the Coxiella-containing
vacuole (CCV). While host cholesterol readily traffics to the CCV, cholesterol accumulation …
vacuole (CCV). While host cholesterol readily traffics to the CCV, cholesterol accumulation …
A treatment to eliminate SARS-CoV-2 replication in human airway epithelial cells is safe for inhalation as an aerosol in healthy human subjects
MD Davis, TM Clemente, OK Giddings, K Ross… - Respiratory …, 2021 - rc.rcjournal.com
BACKGROUND: Low airway surface pH is associated with many airway diseases, impairs
antimicrobial host defense, and worsens airway inflammation. Inhaled Optate is designed to …
antimicrobial host defense, and worsens airway inflammation. Inhaled Optate is designed to …
Cholesterol and pathogens
TM Clemente, SD Gilk - Cholesterol, 2022 - Elsevier
Cholesterol is an essential component of eukaryotic cell membranes as it affects membrane
structural integrity, order, and permeability. Since cholesterol plays an integral role in many …
structural integrity, order, and permeability. Since cholesterol plays an integral role in many …
A high throughput analysis of cytokines and chemokines expression during the course of Trypanosoma cruzi experimental oral infection
…, CS Siqueira, FA Martins, FC Machado, TM Clemente… - Acta tropica, 2016 - Elsevier
Trypanosoma cruzi has high biological and biochemical diversity and variable tissue tropism.
Here we aimed to verify the kinetics of cytokine and chemokine in situ secretion in animals …
Here we aimed to verify the kinetics of cytokine and chemokine in situ secretion in animals …