Mutations of the TP53 gene and dysregulation of the TP53 pathway are important in the
pathogenesis of many human cancers, including lymphomas. Tumor suppression by p53 occurs …

Human follicular 6 cell lymphomas possess at (14; 18) interchromosomal translocation that
juxtaposes the putative proto-oncogene bcl-2 with the immunoglobulin (lg) heavy chain locus…

The significance of apoptosis in relation to the development and progression of prostate
cancer remains largely undefined, bcl-2 is an oncogene that functions by overriding apoptosis. …

Loss of PTEN function leads to activation of phosphoinositide 3-kinase (PI3K) signaling and
Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition …

FOLLICULAR lymphoma, the most common human lymphoma, characteristically has at(14;18)
interchromosomal translocation 1,2 . It is typically an indolent disease comprised of small …

Chronic obstructive pulmonary disease is a common, preventable and treatable disease.
Exercise training programmes (ETPs) improve symptoms, health‐related quality of life (HRQoL) …

Effective anti cancer strategies necessitate the use of agents that target tumor cells rather
than normal tissues. In this study, we constructed a tumor-selective adenovirus, Δ24, that …

The sonic hedgehog (SHH) pathway was first defined genetically in fruit flies. Subsequently,
the SHH network has been shown to be critical for normal mammalian development, by …

Overexpression of the receptor tyrosine kinase p185 ErbB2 confers Taxol resistance in breast
cancers. Here, we investigated the underlying mechanisms and found that overexpression …

Purpose: We designed a prospective single arm Phase II study to evaluate the feasibility and
mechanisms of apoptosis induction after Ad-p53 (INGN 201) gene transfer and radiation …