Preparation of cyclosporine A nanoparticles by evaporative precipitation into aqueous solution

X Chen, TJ Young, M Sarkari, RO Williams III… - International journal of …, 2002 - Elsevier
Amorphous nanoparticle suspensions of a poorly water-soluble drug, cyclosporine A, are
produced by a new process, evaporative precipitation into aqueous solution (EPAS). The rapid …

Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent

…, D Tanabe, S Yamauchi, TJ Young… - AIChE …, 2000 - Wiley Online Library
A new method—rapid expansion from supercritical solution with a nonsolvent (RESS‐N)—is
reported for forming polymer microparticles containing proteins such as lysozyme (from …

Rapid expansion from supercritical to aqueous solution to produce submicron suspensions of water‐insoluble drugs

TJ Young, S Mawson, KP Johnston… - Biotechnology …, 2000 - Wiley Online Library
Stable suspensions of submicron particles of cyclosporine, a water‐insoluble drug, have
been produced by rapid expansion from supercritical to aqueous solution (RESAS). To …

Convective cooling of a heated obstacle in a channel

TJ Young, K Vafai - International Journal of Heat and Mass Transfer, 1998 - Elsevier
A detailed investigation of the forced convective cooling of a heated obstacle mounted upon
a channel wall is presented. The Navier-Stokes equations are used to characterize the flow …

Convective flow and heat transfer in a channel containing multiple heated obstacles

TJ Young, K Vafai - International Journal of Heat and Mass Transfer, 1998 - Elsevier
The present work details the numerical simulation of forced convective, incompressible flow
in a channel with an array of heated obstacles attached to one wall. Three levels of Nusselt …

A novel particle engineering technology to enhance dissolution of poorly water soluble drugs: spray-freezing into liquid

…, J Hu, JN Brown, M Sarkari, TJ Young… - European journal of …, 2002 - Elsevier
A novel cryogenic spray-freezing into liquid (SFL) process was developed to produce
microparticulate powders consisting of an active pharmaceutical ingredient (API) molecularly …

Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1

…, A Dhaka, RJ Heuermann, TJ Young… - Molecular …, 2008 - journals.sagepub.com
Background: A number of prostaglandins (PGs) sensitize dorsal root ganglion (DRG)
neurons and contribute to inflammatory hyperalgesia by signaling through specific G protein-…

Production of HMF, FDCA and their derived products: A review of life cycle assessment (LCA) and techno-economic analysis (TEA) studies

MG Davidson, S Elgie, S Parsons, TJ Young - Green Chemistry, 2021 - pubs.rsc.org
The chemical industry is increasingly looking to develop bio-based alternatives to petroleum-based
platform chemicals, in order to reduce dependence on diminishing fossil resources …

Enhanced aqueous dissolution of a poorly water soluble drug by novel particle engineering technology: Spray-freezing into liquid with atmospheric freeze-drying

TL Rogers, AC Nelsen, M Sarkari, TJ Young… - Pharmaceutical …, 2003 - Springer
Purpose. The purpose of this work was to investigate spray-freezing into liquid (SFL) and
atmospheric freeze-drying (ATMFD) as industrial processes for producing micronized SFL …

Random control clinical trial on the effects of aerobic exercise training on erythrocyte levels during radiation treatment for breast cancer

JS Drouin, TJ Young, J Beeler, K Byrne, TJ Birk… - Cancer, 2006 - Wiley Online Library
BACKGROUND. Erythrocyte changes from aerobic exercise training were examined during
radiation treatment of breast cancer. METHODS. Twenty sedentary females with breast …