Family B of G-protein-coupled receptors (GPCRs) and their ligands play a central role in a
number of homeostatic mechanisms in the endocrine, gastrointestinal, skeletal, immune, …

Introduction : To adhere to the Hippocratic Oath, to ‘first, do no harm’, we need to make every
effort to minimize the adverse effects of mechanical ventilation. Our understanding of the …

Renin–angiotensin aldosterone system inhibitors are for a long time extensively used for
the treatment of cardiovascular and renal diseases. AT1 receptor blockers (ARBs or sartans) …

Postoperative delirium (POD) is an acute alteration of mental state, characterized by reduced
awareness and attention, occurring up to five postoperative days after recovery from …

AT1 antagonists is the most recent drug class of molecules against hypertension and they
mediate their actions through blocking detrimental effects of angiotensin II (A-II) when acts on …

Irbesartan (IRB) exerts beneficial effects either alone or in combination with other drugs on
numerous diseases, such as cancer, diabetes, and hypertension. However, due to its high …

Objectives. Total Knee Replacement Surgery (TKR) is one of the most common elective
orthopedic operations. Postoperative pain after total knee replacement, remains a challenge. In …

Background: Family BG protein-coupled receptors (GPCRs) play an important role in many
physiological and pathophysiological processes. They are plasma-membrane proteins …

Gonadotropin-releasing hormone (GnRH) is pivotal in regulating human reproduction and
fertility through its specific receptors. Among these, gonadotropin-releasing hormone receptor …

Neurotensin (NT) (pGlu–Leu–Tyr–Glu–Asn–Lys–Pro–Arg–Arg–Pro–Tyr–Ile–Leu) exerts a
dual function as a neurotransmitter/neuromodulator in the central nervous system and as a …