Review ArticleInvited Review

Respiratory Sensations in Dynamic Hyperinflation: Physiological and Clinical Applications

Morgan I Soffler, Margaret M Hayes and Richard M Schwartzstein
Respiratory Care September 2017, 62 (9) 1212-1223; DOI: https://doi.org/10.4187/respcare.05198

References

  1. 1.↵
    1. Parshall MB,
    2. Schwartzstein RM,
    3. Adams L,
    4. Banzett RB,
    5. Manning HL,
    6. Bourbeau J,
    7. et al
    . An official American Thoracic society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med 2012;185(4):435–452.
    OpenUrlCrossRefPubMedWeb of Science
  2. 2.↵
    1. O'Donnell DE,
    2. Laveneziana P
    . The clinical importance of dynamic lung hyperinflation in COPD. COPD J Chronic Obstr Pulm Dis 2006;3(4):219–232.
    OpenUrl
  3. 3.↵
    1. Casanova C,
    2. Cote C,
    3. de Torres JP,
    4. Aguirre-Jaime A,
    5. Marin JM,
    6. Pinto-Plata V,
    7. Celli BR
    . Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005;171(6):591–597.
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Ozgür ES,
    2. Nayci SA,
    3. Özge C,
    4. Taşdelen B
    . An integrated index combined by dynamic hyperinflation and exercise capacity in the prediction of morbidity and mortality in COPD. Respir Care 2012;57(9):1452–1459.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Gagnon P,
    2. Guenette JA,
    3. Langer D,
    4. Laviolette L,
    5. Mainguy V,
    6. Maltais F,
    7. et al
    . Pathogenesis of hyperinflation in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014;9:187.
    OpenUrlPubMed
  6. 6.↵
    1. Nishimura K,
    2. Yasui M,
    3. Nishimura T,
    4. Oga T
    . Airflow limitation or static hyperinflation: which is more closely related to dyspnea with activities of daily living in patients with COPD? Respir Res 2011;12(1):135.
    OpenUrlPubMed
  7. 7.↵
    1. Chen R,
    2. Lin L,
    3. Tian J,
    4. Zeng B,
    5. Zhang L,
    6. Chen X,
    7. Yan H
    . Predictors of dynamic hyperinflation during the 6-minute walk test in stable chronic obstructive pulmonary disease patients. J Thorac Dis 2015;7(7):1142–1150.
    OpenUrl
  8. 8.↵
    1. Pepin V,
    2. Saey D,
    3. Laviolette L,
    4. Maltais F
    . Exercise capacity in chronic obstructive pulmonary disease: mechanisms of limitation. COPD 2007;4(3):195–204.
    OpenUrl
  9. 9.↵
    1. Pedersen OF,
    2. Butler JP
    . Expiratory flow limitation. Compr Physiol 2011;1(4):1861–1882.
    OpenUrl
  10. 10.↵
    1. Schwartzstein RM,
    2. Parker MJ
    . Respiratory Physiology: A Clinical Approach. Philadelphia: Lippincott Williams & Wilkins, 2006.
  11. 11.↵
    1. Tantucci C
    . Expiratory flow limitation definition, mechanisms, methods, and significance. Pulm Med 2013;2013:1–6.
    OpenUrl
  12. 12.↵
    1. Macklem PT
    . Hyperinflation. Am Rev Respir Dis 1984;129(1):1–2.
    OpenUrlPubMedWeb of Science
  13. 13.↵
    1. Campbell EJ,
    2. Howell JB
    . The sensation of breathlessness. Br Med Bull 1963;19:36–40.
    OpenUrlPubMedWeb of Science
  14. 14.
    1. Manning HL,
    2. Schwartzstein RM
    . Pathophysiology of dyspnea. N Engl J Med 1995;333(23):1547–1553.
    OpenUrlCrossRefPubMedWeb of Science
  15. 15.↵
    1. Manning HL,
    2. Schwartzstein RM
    . Respiratory sensations in asthma: physiological and clinical implications. J Asthma 2001;38(6):447–460.
    OpenUrlCrossRefPubMedWeb of Science
  16. 16.↵
    1. Banzett RB,
    2. Pedersen SH,
    3. Schwartzstein RM,
    4. Lansing RW
    . The affective dimension of laboratory dyspnea: air hunger is more unpleasant than work/effort. Am J Respir Crit Care Med 2008;177(12):1384–1390.
    OpenUrlCrossRefPubMedWeb of Science
  17. 17.↵
    1. Buchanan GF,
    2. Richerson GB
    . Role of chemoreceptors in mediating dyspnea. Respir Physiol Neurobiol 2009;167(1):1–9.
    OpenUrlPubMed
  18. 18.↵
    1. Mahler DA,
    2. O'Donnell DE
    . Recent advances in dyspnea. Chest 2015;147(1):232–241.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Widdicombe J
    . Lung afferent activity: implications for respiratory sensation. Respir Physiol Neurobiol 2009;167(1):2–8.
    OpenUrlCrossRefPubMedWeb of Science
  20. 20.
    1. Lee LY
    . Respiratory sensations evoked by activation of bronchopulmonary C-fibers. Respir Physiol Neurobiol 2009;167(1):26–35.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.
    1. Simon PM,
    2. Schwartzstein RM,
    3. Weiss JW,
    4. Fencl V,
    5. Teghtsoonian M,
    6. Weinberger SE
    . Distinguishable types of dyspnea in patients with shortness of breath. Am Rev Respir Dis 1990;142(5):1009–1014.
    OpenUrlCrossRefPubMedWeb of Science
  22. 22.↵
    1. Rock LK,
    2. Schwartzstein RM
    . Mechanisms of dyspnea in chronic lung disease. Curr Opin Support Palliat Care 2007;1(2):102–108.
    OpenUrlCrossRefPubMed
  23. 23.↵
    1. Mahler DA,
    2. Harver A,
    3. Lentine T,
    4. Scott JA,
    5. Beck K,
    6. Schwartzstein RM
    . Descriptors of breathlessness in cardiorespiratory diseases. Am J Respir Crit Care Med 1996;154(5):1357–1363.
    OpenUrlCrossRefPubMedWeb of Science
  24. 24.↵
    1. O'Donnell DE,
    2. Guenette JA,
    3. Maltais F,
    4. Webb KA
    . Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise. Chest 2012;141(3):753–762.
    OpenUrlCrossRefPubMed
  25. 25.↵
    1. O'Donnell DE,
    2. Laveneziana P
    . Physiology and consequences of lung hyperinflation in COPD. Eur Respir Rev 2006;15(100):61–67.
    OpenUrlAbstract/FREE Full Text
  26. 26.↵
    1. Yan S
    . Sensation of inspiratory difficulty during inspiratory threshold and hyperinflationary loadings: effect of inspiratory muscle strength. Am J Respir Crit Care Med 1999;160(5):1544–1549.
    OpenUrlPubMedWeb of Science
  27. 27.↵
    1. Killian KJ,
    2. Jones NL
    . Respiratory muscles and dyspnea. Clin Chest Med 1988;9(2):237–248.
    OpenUrlPubMedWeb of Science
  28. 28.↵
    1. Schwartzstein RM,
    2. Manning HL,
    3. Weiss JW,
    4. Weinberger SE
    . Dyspnea: a sensory experience. Lung 1990;168(4):185–199.
    OpenUrlPubMedWeb of Science
  29. 29.↵
    1. Montes de Oca M,
    2. Celli BR
    . Mouth occlusion pressure, CO2 response and hypercapnia in severe chronic obstructive pulmonary disease. Eur Respir J 1998;12(3):666–671.
    OpenUrlAbstract
  30. 30.↵
    1. De Troyer A,
    2. Leeper JB,
    3. McKenzie DK,
    4. Gandevia SC
    . Neural drive to the diaphragm in patients with severe COPD. Am J Respir Crit Care Med 1997;155(4):1335–1340.
    OpenUrlPubMedWeb of Science
  31. 31.↵
    1. O'Donnell DE,
    2. D'Arsigny C,
    3. Fitzpatrick M,
    4. Webb KA
    . Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation. Am J Respir Crit Care Med 2002;166(5):663–668.
    OpenUrlCrossRefPubMedWeb of Science
  32. 32.↵
    1. Caviedes IR,
    2. Delgado I,
    3. Soto R
    . Ventilatory inefficiency as a limiting factor for exercise in patients with COPD. Respir Care 2012;57(4):583–589.
    OpenUrlAbstract/FREE Full Text
  33. 33.↵
    1. Elbehairy AF,
    2. Ciavaglia CE,
    3. Webb KA,
    4. Guenette JA,
    5. Jensen D,
    6. Mourad SM,
    7. et al
    . Pulmonary gas exchange abnormalities in mild chronic obstructive pulmonary disease: implications for dyspnea and exercise intolerance. Am J Respir Crit Care Med 2015;191(12):1384–1394.
    OpenUrlCrossRefPubMed
  34. 34.↵
    1. Zafar MA,
    2. Tsuang W,
    3. Lach L,
    4. Eschenbacher W,
    5. Panos RJ
    . Dynamic hyperinflation correlates with exertional oxygen desaturation in patients with chronic obstructive pulmonary disease. Lung 2013;191(2):177–182.
    OpenUrlPubMed
  35. 35.↵
    1. O'Donnell DE,
    2. Laveneziana P,
    3. Webb K,
    4. Neder JA
    . Chronic obstructive pulmonary disease: clinical integrative physiology. Clin Chest Med 35(1):51–69, 2014.
    OpenUrlCrossRefPubMedWeb of Science
  36. 36.↵
    1. Watz H,
    2. Waschki B,
    3. Meyer T,
    4. Kretschmar G,
    5. Kirsten A,
    6. Claussen M,
    7. Magnussen H
    . Decreasing cardiac chamber sizes and associated heart dysfunction in COPD: role of hyperinflation. Chest 2010;138(1):32–38.
    OpenUrlCrossRefPubMedWeb of Science
  37. 37.↵
    1. Jörgensen K,
    2. Müller MF,
    3. Nel J,
    4. Upton RN,
    5. Houltz E,
    6. Ricksten S-E
    . Reduced intrathoracic blood volume and left and right ventricular dimensions in patients with severe emphysema: an MRI study. Chest 2007;131(4):1050–1057.
    OpenUrlCrossRefPubMedWeb of Science
  38. 38.↵
    1. Aliverti A,
    2. Macklem PT
    . Last word on point:counterpoint: the major limitation to exercise performance in COPD is 1) inadequate energy supply to the respiratory and locomotor muscles, 2) lower limb muscle dysfunction, 3) dynamic hyperinflation. J Appl Physiol 2008;105(3):763.
    OpenUrlFREE Full Text
  39. 39.↵
    Skeletal muscle dysfunction in chronic obstructive pulmonary disease. A statement of the American Thoracic Society and European Respiratory Society. Am J Respir Crit Care Med 1999;159(4):S1–S40.
    OpenUrlPubMedWeb of Science
  40. 40.
    1. Maltais F,
    2. Jobin J,
    3. Sullivan MJ,
    4. Bernard S,
    5. Whittom F,
    6. Killian KJ,
    7. et al
    . Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD. J Appl Physiol 1998;84(5):1573–1580.
    OpenUrlAbstract/FREE Full Text
  41. 41.↵
    1. Aliverti A,
    2. Macklem PT
    . How and why exercise is impaired in COPD. Respir Int Rev Thorac Dis 2001;68(3):229–239.
    OpenUrl
  42. 42.↵
    1. Hulo S,
    2. Inamo J,
    3. Dehon A,
    4. Le Rouzic O,
    5. Edme J-L,
    6. Neviere R
    . Chronotropic incompetence can limit exercise tolerance in COPD patients with lung hyperinflation. Int J Chron Obstruct Pulmon Dis 2016;11:2553–2561.
    OpenUrl
  43. 43.↵
    1. von Leupoldt A,
    2. Sommer T,
    3. Kegat S,
    4. Baumann HJ,
    5. Kose H,
    6. Dahme B,
    7. Büchel C
    . Dyspnea and pain share emotion-related brain network. NeuroImage 2009;48(1):200–206.
    OpenUrlCrossRefPubMedWeb of Science
  44. 44.
    1. Davenport PW,
    2. Vovk A
    . Cortical and subcortical central neural pathways in respiratory sensations. Respir Physiol Neurobiol 2009;167(1):72–86.
    OpenUrlCrossRefPubMedWeb of Science
  45. 45.↵
    1. Evans KC,
    2. Banzett RB,
    3. Adams L,
    4. McKay L,
    5. Frackowiak RSJ,
    6. Corfield DR
    . BOLD fMRI identifies limbic, paralimbic, and cerebellar activation during air hunger. J Neurophysiol 2002;88(3):1500–1511.
    OpenUrlAbstract/FREE Full Text
  46. 46.↵
    1. Cooper CB,
    2. Calligaro GL,
    3. Quinn MM,
    4. Eshaghian P,
    5. Coskun F,
    6. Abrazado M,
    7. et al
    . Determinants of dynamic hyperinflation during metronome-paced tachypnea in COPD and normal subjects. Respir Physiol Neurobiol 2014;190:76–80.
    OpenUrl
  47. 47.↵
    1. Calligaro GL,
    2. Raine RI,
    3. Bateman ME,
    4. Bateman ED,
    5. Cooper CB
    . Comparing dynamic hyperinflation and associated dyspnea induced by metronome-paced tachypnea versus incremental exercise. COPD 2014;11(1):105–112.
    OpenUrlCrossRef
  48. 48.↵
    1. Leith DE,
    2. Brown R
    . Human lung volumes and the mechanisms that set them. Eur Respir J 1999;13:468–472.
    OpenUrlAbstract
  49. 49.↵
    1. Marin JM,
    2. Carrizo SJ,
    3. Gascon M,
    4. Sanchez A,
    5. Gallego B,
    6. Celli BR
    . Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;163(6):1395–1399.
    OpenUrlCrossRefPubMedWeb of Science
  50. 50.↵
    1. Callens E,
    2. Graba S,
    3. Gillet-Juvin K,
    4. Essalhi M,
    5. Bidaud-Chevalier B,
    6. Peiffer C,
    7. et al
    . Measurement of dynamic hyperinflation after a 6-minute walk test in patients with COPD. Chest 2009;136(6):1466–1472.
    OpenUrlCrossRefPubMedWeb of Science
  51. 51.↵
    1. O'Donnell DE,
    2. Elbehairy AF,
    3. Faisal A,
    4. Webb KA,
    5. Neder JA,
    6. Mahler DA
    . Exertional dyspnoea in COPD: the clinical utility of cardiopulmonary exercise testing. Eur Respir Rev 2016;25(141):333–347.
    OpenUrlAbstract/FREE Full Text
  52. 52.↵
    1. Gelb AF,
    2. Gutierrez CA,
    3. Weisman IM,
    4. Newsom R,
    5. Taylor CF,
    6. Zamel N
    . Simplified detection of dynamic hyperinflation. Chest 2004;126(6):1855–1860.
    OpenUrlCrossRefPubMedWeb of Science
  53. 53.↵
    1. Lahaije AJMC,
    2. Willems LM,
    3. van Hees HWH,
    4. Dekhuijzen PNR,
    5. Heidra YF
    . Diagnostic accuracy of metronome-paced tachypnea to detect dynamic hyperinflation. Clin Physiol Funct Imaging 2013;33(1)62–69.
    OpenUrl
  54. 54.↵
    1. Lahaije A,
    2. van Helvoort H,
    3. Dekhuijzen R,
    4. Heijdra Y
    . Can COPD patients who hyperinflate during daily life activities be identified by laboratory tests? Respir Int Rev Thorac Dis 2013;86(3):237–242.
    OpenUrl
  55. 55.↵
    1. O'Donnell DE,
    2. Hamilton AL,
    3. Webb KA
    . Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD. J Appl Physiol 2006;101(4):1025–1035.
    OpenUrlAbstract/FREE Full Text
  56. 56.↵
    1. O'Donnell DE,
    2. Lam M,
    3. Webb KA
    . Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999;160(2):542–549.
    OpenUrlCrossRefPubMedWeb of Science
  57. 57.
    1. O'Donnell DE,
    2. Lam M,
    3. Webb KA
    . Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;158(5):1557–1565.
    OpenUrlCrossRefPubMedWeb of Science
  58. 58.↵
    1. O'Donnell DE,
    2. Flüge T,
    3. Gerken F,
    4. Hamilton A,
    5. Webb K,
    6. Aguilaniu B,
    7. et al
    . Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 2004;23(6):832–840.
    OpenUrlAbstract/FREE Full Text
  59. 59.↵
    1. Laveneziana P,
    2. Palange P,
    3. Ora J,
    4. Martolini D,
    5. O'Donnell DE
    . Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD. Eur J Appl Physiol 2009;107(6):633–643.
    OpenUrlCrossRefPubMed
  60. 60.↵
    1. Sanguinetti CM
    . The lungs need to be deflated: effects of glycopyrronium on lung hyperinflation in COPD patients. Multidiscip Respir Med 2014;9(1):19.
    OpenUrl
  61. 61.↵
    1. Berton DC,
    2. Barbosa PB,
    3. Takara LS,
    4. Chiappa GR,
    5. Siqueira ACB,
    6. Bravo DM,
    7. et al
    . Bronchodilators accelerate the dynamics of muscle O2 delivery and utilisation during exercise in COPD. Thorax 2010;65(7):588–593.
    OpenUrlAbstract/FREE Full Text
  62. 62.
    1. Chiappa GR,
    2. Queiroga F,
    3. Meda E,
    4. Ferreira LF,
    5. Diefenthaeler F,
    6. Nunes M,
    7. et al
    . Heliox improves oxygen delivery and utilization during dynamic exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009;179(11):1004–1010.
    OpenUrlCrossRefPubMedWeb of Science
  63. 63.↵
    1. Vogiatzis I,
    2. Habazett H,
    3. Aliverti A,
    4. Anthanasopoulos D,
    5. Louvaris Z,
    6. LoMauro A,
    7. et al
    . Effect of helium breathing on intercostal and quadriceps muscle blood flow during exercise in COPD patients. Am J Physiol Regul Integr Comp Physiol 2011;300(6):R1549–R1559.
    OpenUrlAbstract/FREE Full Text
  64. 64.↵
    1. Banzett RB,
    2. Adams L,
    3. O'Donnell CR,
    4. Gilman SA,
    5. Lansing RW,
    6. Schwartzstein RM
    . Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response. Am J Respir Crit Care Med 2011;184(8):920–927.
    OpenUrlCrossRefPubMedWeb of Science
  65. 65.↵
    1. Pattinson KTS,
    2. Governo RJ,
    3. MacIntosh BJ,
    4. Russell EC,
    5. Corfield DR,
    6. Tracey I,
    7. Wise RG
    . Opioids Depress cortical centers responsible for the volitional control of respiration. J Neurosci 2009;29(25):8177–8186.
    OpenUrlAbstract/FREE Full Text
  66. 66.↵
    1. Jennings A-L,
    2. Davies AN,
    3. Higgins JPT,
    4. Gibbs JSR,
    5. Broadley KE
    . A systematic review of the use of opioids in the management of dyspnoea. Thorax 2002;57(11):939–944.
    OpenUrlAbstract/FREE Full Text
  67. 67.↵
    1. Mahler DA
    . Opioids for refractory dyspnea. Expert Rev Respir Med 2013;7(2):123–134.
    OpenUrlCrossRefPubMed
  68. 68.↵
    1. Abernethy AP,
    2. Currow DC,
    3. Frith P,
    4. Fazekas BS,
    5. McHugh A,
    6. Bui C
    . Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ 2003;327(7414):523–528.
    OpenUrlAbstract/FREE Full Text
  69. 69.↵
    1. Cabezón-Gutiérrez L,
    2. Khosravi-Shahi P,
    3. Custodio-Cabello S,
    4. Muñiz-González F,
    5. Cano-Aguirre MP,
    6. Alonso-Viteri S
    . Opioids for management of episodic breathlessness or dyspnea in patients with advanced disease. Support Care Cancer 2016;24(9):4045–4055.
    OpenUrl
  70. 70.↵
    1. Janssen DJA,
    2. Spruit MA,
    3. Uszko-Lencer NH,
    4. Schols JMGA,
    5. Wouters EFM
    . Symptoms, comorbidities, and health care in advanced chronic obstructive pulmonary disease or chronic heart failure. J Palliat Med 2011;14(6):735–743.
    OpenUrlCrossRefPubMed
  71. 71.↵
    1. Soffler MI,
    2. Rose A,
    3. Hayes MM,
    4. Banzett RB,
    5. Schwartzstein RM
    . Treatment of acute dyspnea with morphine to avert respiratory failure. Ann Am Thorac Soc 2017;14(4):584–588.
    OpenUrl
  72. 72.↵
    1. Kallet RH
    . The role of inhaled opioids and furosemide for the treatment of dyspnea. Respir Care 2007;52(7):900–910.
    OpenUrlAbstract/FREE Full Text
  73. 73.↵
    1. Kohara H,
    2. Euoka H,
    3. Aoe K,
    4. Maeda T,
    5. Takeyama H,
    6. Saito R,
    7. et al
    . Effect of nebulized furosemide in terminally ill cancer patients with dyspnea. J Pain Symptom Manage 2003;26(4):962–967.
    OpenUrlCrossRefPubMedWeb of Science
  74. 74.↵
    1. Ong K-C,
    2. Kor A-C,
    3. Chong W-F,
    4. Earnest A,
    5. Wang Y-T
    . Effects of inhaled furosemide on exertional dyspnea in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004;169(9):1028–1033.
    OpenUrlCrossRefPubMedWeb of Science
  75. 75.↵
    1. Jensen D,
    2. Amjadi K,
    3. Harris-McAllister V,
    4. Webb KA,
    5. O'Donnell DE
    . Mechanisms of dyspnea relief and improved exercise endurance after furosemide inhalation in COPD. Thorax 2008;63(7):606–613.
    OpenUrlAbstract/FREE Full Text
  76. 76.↵
    1. Nasis I,
    2. Kortianou E,
    3. Vasilopoulou M,
    4. Spetsioti S,
    5. Louvaris Z,
    6. Kaltsakas G,
    7. et al
    . Hemodynamic effects of high intensity interval training in COPD patients exhibiting exercise-induced dynamic hyperinflation. Respir Physiol Neurobiol 2015;217:8–16.
    OpenUrlCrossRefPubMed
  77. 77.
    1. Porszasz J,
    2. Emtner M,
    3. Goto S,
    4. Somfay A,
    5. Whipp BJ,
    6. Casaburi R
    . Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD. Chest 2005;128(4):2025–2034.
    OpenUrlCrossRefPubMedWeb of Science
  78. 78.
    1. Ramponi S,
    2. Tzani P,
    3. Aiello M,
    4. Marangio E,
    5. Clini E,
    6. Chetta A
    . Pulmonary rehabilitation improves cardiovascular response to exercise in COPD. Respir Int Rev Thorac Dis 2013;86(1):17–24.
    OpenUrl
  79. 79.↵
    1. Lötters F,
    2. van Tol B,
    3. Kwakkel G,
    4. Gosselink R
    . Effects of controlled inspiratory muscle training in patients with COPD: a meta-analysis. Eur Respir J 2002;20(3):570–576.
    OpenUrlAbstract/FREE Full Text
  80. 80.↵
    1. Chun EM,
    2. Han SJ,
    3. Modi HN
    . Analysis of diaphragmatic movement before and after pulmonary rehabilitation using fluoroscopy imaging in patients with COPD. Int J Chron Obstruct Pulmon Dis 2015;10:193–199.
    OpenUrl
  81. 81.↵
    1. Fagevik Olsén M,
    2. Lannefors L,
    3. Westerdahl E
    . Positive expiratory pressure – Common clinical applications and physiological effects. Respir Med 2015;109(3):297–307.
    OpenUrlPubMed
  82. 82.↵
    1. Monteiro MB,
    2. Berton DC,
    3. Moreira MAF,
    4. Menna-Barreto SS,
    5. Teixeira PJZ
    . Effects of expiratory positive airway pressure on dynamic hyperinflation during exercise in patients with COPD. Respir Care 2012;57(9):1405–1412.
    OpenUrlAbstract/FREE Full Text
  83. 83.↵
    1. Faager G,
    2. Stâhle A,
    3. Larsen FF
    . Influence of spontaneous pursed lips breathing on walking endurance and oxygen saturation in patients with moderate to severe chronic obstructive pulmonary disease. Clin Rehabil 2008;22(8):675–683.
    OpenUrlCrossRefPubMed
  84. 84.↵
    1. Tiep BL,
    2. Burns M,
    3. Kao D,
    4. Madison R,
    5. Herrera J
    . Pursed lips breathing training using ear oximetry. Chest 1986;90(2):218–221.
    OpenUrlCrossRefPubMedWeb of Science
  85. 85.↵
    1. Cabral LF,
    2. D'Elia TDC,
    3. Marins DDS,
    4. Zin WA,
    5. Guimarães FS
    . Pursed lip breathing improves exercise tolerance in COPD: a randomized crossover study. Eur J Phys Rehabil Med 2015;51(1):79–88.
    OpenUrl
  86. 86.↵
    1. Marchetti N,
    2. Lammi MR,
    3. Travaline JM,
    4. Ciccolella D,
    5. Civic B,
    6. Criner GJ
    . Air current applied to the face improves exercise performance in patients with COPD. Lung 2015;193(5):725–731.
    OpenUrl
  87. 87.↵
    1. Ram FSF,
    2. Picot J,
    3. Lightowler J,
    4. Wedzicha JA
    . Non-invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2004;(3):CD004104.
  88. 88.↵
    1. Barnes PJ
    . GOLD 2017: a new report. Chest 2017;151(2):245–246.
    OpenUrl
  89. 89.↵
    1. van 't Hul A,
    2. Kwakkel G,
    3. Gosselink R
    . The acute effects of noninvasive ventilatory support during exercise on exercise endurance and dyspnea in patients with chronic obstructive pulmonary disease: a systematic review. J Cardiopulm Rehabil 2002;22(4):290–297.
    OpenUrlCrossRefPubMed
  90. 90.↵
    1. Díaz O,
    2. Ramos J,
    3. Gallardo J,
    4. Torrealba B,
    5. Lisboa C
    . [Non-invasive mechanical ventilation in patients with severe stable COPD]. Rev Med Chil 1999;127(6):647–654.
    OpenUrlPubMedWeb of Science
  91. 91.↵
    1. Díaz O,
    2. Bégin P,
    3. Torrealba B,
    4. Jover E,
    5. Lisboa C
    . Effects of noninvasive ventilation on lung hyperinflation in stable hypercapnic COPD. Eur Respir J 2002;20(6):1490–1498.
    OpenUrlAbstract/FREE Full Text
  92. 92.↵
    1. Petrof BJ,
    2. Calderini E,
    3. Gottfried SB
    . Effect of CPAP on respiratory effort and dyspnea during exercise in severe COPD. J Appl Physiol 1990;69(1):179–188.
    OpenUrlAbstract/FREE Full Text
  93. 93.↵
    1. O'Donoghue FJ,
    2. Catcheside PG,
    3. Jordan AS,
    4. Bersten AD,
    5. McEvoy RD
    . Effect of CPAP on intrinsic PEEP, inspiratory effort, and lung volume in severe stable COPD. Thorax 2002;57(6):533–539.
    OpenUrlAbstract/FREE Full Text
  94. 94.↵
    1. Emery CF,
    2. Schein RL,
    3. Hauck ER,
    4. MacIntyre NR
    . Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary disease. Health Psychol 1998;17(3):232–240.
    OpenUrlCrossRefPubMedWeb of Science
  95. 95.↵
    1. Paz-Díaz H,
    2. Montes de Oca M,
    3. López JM,
    4. Celli BR
    . Pulmonary rehabilitation improves depression, anxiety, dyspnea and health status in patients with COPD. Am J Phys Med Rehabil 2007;86(1):30–36.
    OpenUrlCrossRefPubMedWeb of Science
  96. 96.
    1. Luk EK,
    2. Khan F,
    3. Irving L
    . Maintaining gains following pulmonary rehabilitation. Lung 2015;193(5):709–715.
    OpenUrl
  97. 97.↵
    1. Bhandari NJ,
    2. Jain T,
    3. Marolda C,
    4. ZuWallack RL
    . Comprehensive pulmonary rehabilitation results in clinically meaningful improvements in anxiety and depression in patients with chronic obstructive pulmonary disease. J Cardiopulm Rehabil Prev 2013;33(2):123–127.
    OpenUrl
  98. 98.↵
    1. von Leupoldt A,
    2. Fritzsche A,
    3. Trueba AF,
    4. Meuret AE,
    5. Ritz T
    . Behavioral medicine approaches to chronic obstructive pulmonary disease. Ann Behav Med 2012;44(1):52–65.
    OpenUrlCrossRefPubMed
  99. 99.↵
    1. Brantigan OC,
    2. Mueller E
    . Surgical treatment of pulmonary emphysema. Am Surg 1957;23(9):789–804.
    OpenUrlPubMed
  100. 100.↵
    1. Hopkinson NS,
    2. Toma TP,
    3. Hansell DM,
    4. Goldstraw P,
    5. Moxham J,
    6. Geddes DM,
    7. Polkey MI
    . Effect of bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysema. Am J Respir Crit Care Med 2005;171(5):453–460.
    OpenUrlCrossRefPubMedWeb of Science
  101. 101.
    1. Shah PL,
    2. Herth FJ,
    3. van Geffen WH,
    4. Deslee G,
    5. Slebos D-J
    . Lung volume reduction for emphysema. Lancet Respir Med 2017;5(2):147–156.
    OpenUrl
  102. 102.
    1. Toma TP,
    2. Hopkinson NS,
    3. Hillier J,
    4. Hansell DM,
    5. Morgan C,
    6. Goldstraw PG,
    7. et al
    . Bronchoscopic volume reduction with valve implants in patients with severe emphysema. Lancet 2003;361(9361):931–933.
    OpenUrlCrossRefPubMedWeb of Science
  103. 103.
    1. Pompeo E,
    2. Marino M,
    3. Nofroni I,
    4. Matteucci G,
    5. Mineo TC
    . Reduction pneumoplasty versus respiratory rehabilitation in severe emphysema: a randomized study. Pulmonary Emphysema Research Group. Ann Thorac Surg 2000;70(3):948–953.
    OpenUrlCrossRefPubMedWeb of Science
  104. 104.↵
    1. Martinez FJ,
    2. de Oca MM,
    3. Whyte RI,
    4. Stetz J,
    5. Gay SE,
    6. Celli BR
    . Lung-volume reduction improves dyspnea, dynamic hyperinflation, and respiratory muscle function. Am J Respir Crit Care Med 1997;155(6):1984–1990.
    OpenUrlCrossRefPubMedWeb of Science
  105. 105.↵
    1. Lammi MR,
    2. Marchetti N,
    3. Criner GJ
    . Reduced dynamic hyperinflation after LVRS is associated with improved exercise tolerance. Respir Med 2014;108(10):1491.
    OpenUrl
  106. 106.↵
    1. Jörgensen K,
    2. Houltz E,
    3. Westfelt U,
    4. Nilsson F,
    5. Scherstèn H,
    6. Ricksten S-E
    . Effects of lung volume reduction surgery on left ventricular diastolic filling and dimensions in patients with severe emphysema. Chest 2003;124(5):1863–1870.
    OpenUrlCrossRefPubMedWeb of Science
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