Evaluation of Changes in Frequency, D-CPAP, and Flow and Measured MAP on FIO2 Using Intrapulmonary Percussive Ventilation

Abstract

Background: Intrapulmonary percussive ventilation (IPV) is an airway clearance modality designed to assist in mucus removal and lung recruitment. Frequency, CPAP and flow are adjusted to target small and large airways. The IPV 2C incorporates demand CPAP flow controls, and a variable I:E ratio. The purpose of this study is to evaluate the effects of Demand CPAP, flow and frequency changes on FIO₂. Methods: An IPV 2C and Phasitron 5, (Percussionaire, Sandpoint, ID) were connected to a calibrated Maxtec O2ME oxygen monitor (Maxtec, Salt Lake City, UT) and an Airlife 1L Baby Safe flow-inflating resuscitation bag (Vyaire, Mettawa, IL). Using a constant inspiratory time, FIO₂ was measured after stabilization at frequency <350 and > 350, and D-CPAP and flow at 3 setting changes. Mean airway pressures (MAP) and frequency was derived from the multimeter on the IPV 2C. Descriptive statistics, Mean and Standard Deviations for frequency, flow and D-CPAP were calculated and a paired t-test was performed with a statistical significance level set at P < .05 for each test. Results: There was no statistically significant difference in measured FIO₂ with changes in frequency (P = .74), nor with demand CPAP (P = .61) independently but a significant difference in FIO₂ as flow (P = .006) was added and MAP (P = .02). Conclusions: Despite differences in delivered FIO₂ during IPV, within the acceptable margin of error for an oxygen monitor, IPV delivers a stable and consistent FIO₂ for patients requiring <80% regardless of setting changes.