Feasibility of Delivering a 5-Day Normobaric Hypoxia Breathing in Healthy Volunteers in a Hospital Setting

Lorenzo Berra; Kyle J Medeiros; Francesco Marrazzo; Sarvagna Patel; David Imber; Emanuele Rezoagli; Binglan Yu; Abraham Sonny; Edward A Bittner; Daniel Fisher; Daniel Chipman; Rohit Sharma; Hardik Shah; Brianna E Gray; N Stuart Harris; Fumito Ichinose; Vamsi K Mootha

doi:10.4187/respcare.11928

Research ArticleOriginal Research

Feasibility of Delivering a 5-Day Normobaric Hypoxia Breathing in Healthy Volunteers in a Hospital Setting

Lorenzo Berra, Kyle J Medeiros, Francesco Marrazzo, Sarvagna Patel, David Imber, Emanuele Rezoagli, Binglan Yu, Abraham Sonny, Edward A Bittner, Daniel Fisher, Daniel Chipman, Rohit Sharma, Hardik Shah, Brianna E Gray, N Stuart Harris, Fumito Ichinose and Vamsi K Mootha

Respiratory Care July 2024, respcare.11928; DOI: https://doi.org/10.4187/respcare.11928

Lorenzo Berra

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Harvard Medical School, Boston, Massachusetts.

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For correspondence: lberra@mgh.harvard.edu

Kyle J Medeiros

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

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Francesco Marrazzo

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Harvard Medical School, Boston, Massachusetts.

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Sarvagna Patel

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Harvard Medical School, Boston, Massachusetts.

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David Imber

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Harvard Medical School, Boston, Massachusetts.

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Emanuele Rezoagli

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Harvard Medical School, Boston, Massachusetts.

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Binglan Yu

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

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Abraham Sonny

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Harvard Medical School, Boston, Massachusetts.

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Edward A Bittner

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Harvard Medical School, Boston, Massachusetts.

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Daniel Fisher

Department of Respiratory Care, Massachusetts General Hospital, Boston, Massachusetts.

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Daniel Chipman

Department of Respiratory Care, Massachusetts General Hospital, Boston, Massachusetts.

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Rohit Sharma

Harvard Medical School, Boston, Massachusetts.

Department of Systems Biology, Massachusetts General Hospital, Boston, Massachusetts.

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

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Hardik Shah

Harvard Medical School, Boston, Massachusetts.

Department of Systems Biology, Massachusetts General Hospital, Boston, Massachusetts.

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Metabolomics Platform, Comprehensive Cancer Center, The University of Chicago, Chicago, Illinois.

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Brianna E Gray

Translational and Clinical Research Centers, Massachusetts General Hospital, Boston, Massachusetts.

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N Stuart Harris

Harvard Medical School, Boston, Massachusetts.

Division of Wilderness Medicine, Massachusetts General Hospital, Boston, Massachusetts.

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Fumito Ichinose

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Harvard Medical School, Boston, Massachusetts.

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Vamsi K Mootha

Harvard Medical School, Boston, Massachusetts.

Department of Systems Biology, Massachusetts General Hospital, Boston, Massachusetts.

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

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Feasibility of Delivering a 5-Day Normobaric Hypoxia Breathing in Healthy Volunteers in a Hospital Setting

Respiratory Care Jul 2024, respcare.11928; DOI: 10.4187/respcare.11928

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Feasibility of Delivering a 5-Day Normobaric Hypoxia Breathing in Healthy Volunteers in a Hospital Setting

Respiratory Care Jul 2024, respcare.11928; DOI: 10.4187/respcare.11928

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high-altitude
hypoxia
hypoxemia
hypoxia-inducible factor
pulmonary hypertension

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