Short-Term Appraisal of the Effects and Safety of Manual Versus Ventilator Hyperinflation in an Animal Model of Severe Pneumonia

Gianluigi Li Bassi; Joan Daniel Martí; Talitha Comaru; Eli Aguilera-Xiol; Montserrat Rigol; George Ntoumenopoulos; Silvia Terraneo; Francesca De Rosa; Mariano Rinaudo; Laia Fernandez-Barat; Denise Battaglini; Andrea Meli; Miguel Ferrer; Paolo Pelosi; Davide Chiumello; Antoni Torres

doi:10.4187/respcare.06487

Research ArticleOriginal Research

Short-Term Appraisal of the Effects and Safety of Manual Versus Ventilator Hyperinflation in an Animal Model of Severe Pneumonia

Gianluigi Li Bassi, Joan Daniel Martí, Talitha Comaru, Eli Aguilera-Xiol, Montserrat Rigol, George Ntoumenopoulos, Silvia Terraneo, Francesca De Rosa, Mariano Rinaudo, Laia Fernandez-Barat, Denise Battaglini, Andrea Meli, Miguel Ferrer, Paolo Pelosi, Davide Chiumello and Antoni Torres

Respiratory Care July 2019, 64 (7) 760-770; DOI: https://doi.org/10.4187/respcare.06487

Gianluigi Li Bassi

Hospital Clínic, Thorax Institute, Department of Pulmonary and Critical Care Medicine, Division of Animal Experimentation, Barcelona, Spain.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Centro de Investigación Biomedica En Red- Enfermedades Respiratorias (CIBERES), Barcelona, Spain.

University of Barcelona, Barcelona, Spain.

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Joan Daniel Martí

Hospital Clínic, Thorax Institute, Department of Pulmonary and Critical Care Medicine, Division of Animal Experimentation, Barcelona, Spain.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Centro de Investigación Biomedica En Red- Enfermedades Respiratorias (CIBERES), Barcelona, Spain.

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Talitha Comaru

Instituto Federal Farroupilha/Campus Santo Ângelo, Santa Maria, Brazil.

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Eli Aguilera-Xiol

Hospital Clínic, Thorax Institute, Department of Pulmonary and Critical Care Medicine, Division of Animal Experimentation, Barcelona, Spain.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Centro de Investigación Biomedica En Red- Enfermedades Respiratorias (CIBERES), Barcelona, Spain.

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Montserrat Rigol

Hospital Clínic, Thorax Institute, Department of Pulmonary and Critical Care Medicine, Division of Animal Experimentation, Barcelona, Spain.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Hospital Clínic, Thorax Institute, Cardiology Department, Barcelona, Spain.

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George Ntoumenopoulos

Physiotherapy Department, Guy's & St Thomas' NHS Foundation Trust, United Kingdom, and the Physiotherapy Services Critical Care, St Vincent's Hospital Sydney, Sydney, Australia.

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Silvia Terraneo

Hospital Clínic, Thorax Institute, Department of Pulmonary and Critical Care Medicine, Division of Animal Experimentation, Barcelona, Spain.

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Francesca De Rosa

Hospital Clínic, Thorax Institute, Department of Pulmonary and Critical Care Medicine, Division of Animal Experimentation, Barcelona, Spain.

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Mariano Rinaudo

Hospital Clínic, Thorax Institute, Department of Pulmonary and Critical Care Medicine, Division of Animal Experimentation, Barcelona, Spain.

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Laia Fernandez-Barat

Hospital Clínic, Thorax Institute, Department of Pulmonary and Critical Care Medicine, Division of Animal Experimentation, Barcelona, Spain.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Centro de Investigación Biomedica En Red- Enfermedades Respiratorias (CIBERES), Barcelona, Spain.

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Denise Battaglini

Dipartimento Scienze Chirurgiche e Diagnostiche Integrate (DISC), Università degli Studi di Genova, Genova, Italia.

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Andrea Meli

Dipartimento di Anestesia e Rianimazione, ASST Santi Paolo e Carlo, Dipartimento di Scienza e Salute – Universita degli Studi di Milano, Milan, Italy.

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Miguel Ferrer

Hospital Clínic, Thorax Institute, Department of Pulmonary and Critical Care Medicine, Division of Animal Experimentation, Barcelona, Spain.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Centro de Investigación Biomedica En Red- Enfermedades Respiratorias (CIBERES), Barcelona, Spain.

University of Barcelona, Barcelona, Spain.

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Paolo Pelosi

Dipartimento Scienze Chirurgiche e Diagnostiche Integrate (DISC), Università degli Studi di Genova, Genova, Italia.

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Davide Chiumello

Dipartimento di Anestesia e Rianimazione, ASST Santi Paolo e Carlo, Dipartimento di Scienza e Salute – Universita degli Studi di Milano, Milan, Italy.

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Antoni Torres

Hospital Clínic, Thorax Institute, Department of Pulmonary and Critical Care Medicine, Division of Animal Experimentation, Barcelona, Spain.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Centro de Investigación Biomedica En Red- Enfermedades Respiratorias (CIBERES), Barcelona, Spain.

University of Barcelona, Barcelona, Spain.

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For correspondence: atorres@clinic.ub.es

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Short-Term Appraisal of the Effects and Safety of Manual Versus Ventilator Hyperinflation in an Animal Model of Severe Pneumonia

Respiratory Care Jul 2019, 64 (7) 760-770; DOI: 10.4187/respcare.06487

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Short-Term Appraisal of the Effects and Safety of Manual Versus Ventilator Hyperinflation in an Animal Model of Severe Pneumonia

Respiratory Care Jul 2019, 64 (7) 760-770; DOI: 10.4187/respcare.06487

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mechanical ventilation
hyperinflation
mucus clearance
pneumonia
atelectasis
pulmonary mechanic

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