Wet-Side Breath-Enhanced Jet Nebulization: Controlling Drug Delivery During Mechanical Ventilation

References

1. 1.↵
   1. Ari A,
   2. Atalay OT,
   3. Harwood R,
   4. Sheard MM,
   5. Aljamhan EA,
   6. Fink JB

   . Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care 2010;55(7):845-851.

   OpenUrlAbstract/FREE Full Text
2. 2.↵
   1. Ari A,
   2. Areabi H,
   3. Fink JB

   . Evaluation of aerosol generator devices at 3 locations in humidified and non-humidified circuits during adult mechanical ventilation. Respir Care 2010;55(7):837-844.

   OpenUrlAbstract/FREE Full Text
3. 3.
   1. Hughes J,
   2. Saez T

   . Effects of nebulizer mode and position in a mechanical ventilator circuit on dose efficiency. Respir Care 1987;32(12):1131-1135.

   OpenUrl
4. 4.↵
   1. Berlinski A,
   2. Willis JR

   . Albuterol delivery by 4 different nebulizers placed in 4 different positions in a pediatric ventilator in vitro model. Respir Care 2013;58(7):1124-1133.

   OpenUrlAbstract/FREE Full Text
5. 5.↵
   1. Miller DD,
   2. Amin MM,
   3. Palmer LB,
   4. Shah AR,
   5. Smaldone GC

   . Aerosol delivery and modern mechanical ventilation: in vitro/in vivo evaluation. Am J Respir Crit Care Med 2003;168(10):1205-1209.

   OpenUrlCrossRefPubMedWeb of Science
6. 6.↵
   1. O'Riordan TG,
   2. Palmer LB,
   3. Smaldone GC

   . Aerosol deposition in mechanically ventilated patients. Optimizing nebulizer delivery. Am J Respir Crit Care Med 1994;149(1):214-219.

   OpenUrlPubMedWeb of Science
7. 7.↵
   1. O'Riordan TG,
   2. Greco MJ,
   3. Perry RJ,
   4. Smaldone GC

   . Nebulizer function during mechanical ventilation. Am Rev Respir Dis 1992;145(5):1117-1122.

   OpenUrlCrossRefPubMedWeb of Science
8. 8.↵
   1. Diot P,
   2. Morra L,
   3. Smaldone GC

   . Albuterol delivery in a model of mechanical ventilation. Comparison of metered-dose inhaler and nebulizer efficiency. Am J Respir Crit Care Med 1995;152(4 Pt 1):1391-1394.

   OpenUrlCrossRefPubMedWeb of Science
9. 9.↵
   1. O'Doherty MJ,
   2. Thomas SH,
   3. Page CJ,
   4. Treacher DF,
   5. Nunan TO

   . Delivery of a nebulized aerosol to a lung model during mechanical ventilation. Effect of ventilator settings and nebulizer type, position, and volume of fill. Am Rev Respir Dis 1992;146(2):383-388.

   OpenUrlPubMedWeb of Science
10. 10.↵
    1. Ari A,
    2. Fink JB

    . Factors affecting bronchodilator delivery in mechanically ventilated adults. Nurs Crit Care 2010;15(4):192-203.

    OpenUrlPubMed
11. 11.↵
    1. Berlinski A,
    2. Willis JR

    . Effect of tidal volume and nebulizer type and position on albuterol delivery in a pediatric model of mechanical ventilation. Respir Care 2015;60(10):1424-1430.

    OpenUrlAbstract/FREE Full Text
12. 12.↵
    1. McPeck M,
    2. O’Riordan T,
    3. Smaldone GC

    . Choice of mechanical ventilator: influence on nebulizer performance. Respir Care 1993;38(8):887-895.

    OpenUrl
13. 13.↵
    1. Ehrmann S,
    2. Lyazidi A,
    3. Louis B,
    4. Isabey D,
    5. Le Pennec D,
    6. Brochard L,
    7. Apiou-Sbirlea G

    . Ventilator-integrated jet nebulization systems: tidal volume control and efficiency of synchronization. Respir Care 2014;59(10):1508-1516.

    OpenUrlAbstract/FREE Full Text
14. 14.↵
    1. Gowda AA,
    2. Cuccia AD,
    3. Smaldone GC

    . Reliability of vibrating mesh technology. Respir Care 2017;62(1):65-69.

    OpenUrlAbstract/FREE Full Text
15. 15.↵
    1. Hess D,
    2. Fisher D,
    3. Williams P,
    4. Pooler S,
    5. Kacmarek RM

    . Medication nebulizer performance. Effects of diluent volume, nebulizer flow, and nebulizer brand. Chest 1996;110(2):498-505.

    OpenUrlCrossRefPubMedWeb of Science
16. 16.↵
    1. Ehrmann S,
    2. Chastre J,
    3. Diot P,
    4. Lu Q

    . Nebulized antibiotics in mechanically ventilated patients: a challenge for translational research from technology to clinical care. Ann Intensive Care 2017;7(1):78.

    OpenUrl
17. 17.
    1. Anderson AC,
    2. Dubosky MN,
    3. Fiorino KA,
    4. Quintana V,
    5. Kaplan CA,
    6. Vines DL

    . The effect of nebulizer position on aerosolized epoprostenol delivery in an adult lung model. Respir Care 2017;62(11):1387-1395.

    OpenUrlAbstract/FREE Full Text
18. 18.
    1. Ari A,
    2. Alwadeai KS,
    3. Fink JB

    . Effects of heat and moisture exchangers and exhaled humidity on aerosol deposition in a simulated ventilator-dependent adult lung model. Respir Care 2017;62(5):538-543.

    OpenUrlAbstract/FREE Full Text
19. 19.
    1. Dugernier J,
    2. Wittebole X,
    3. Roeseler J,
    4. Michotte JB,
    5. Sottiaux T,
    6. Dugernier T,
    7. et al

    . Influence of inspiratory flow pattern and nebulizer position on aerosol delivery with a vibrating-mesh nebulizer during invasive mechanical ventilation: an in vitro analysis. J Aerosol Med Pulm Drug Deliv 2015;28(3):229-236.

    OpenUrl
20. 20.
    1. Pedersen KM,
    2. Handlos VN,
    3. Heslet L,
    4. Kristensen HG

    . Factors influencing the in vitro deposition of tobramycin aerosol: a comparison of an ultrasonic nebulizer and a high-frequency vibrating mesh nebulizer. J Aerosol Med 2006;19(2):175-183.

    OpenUrlPubMedWeb of Science
21. 21.↵
    1. Wan GH,
    2. Lin HL,
    3. Fink JB,
    4. Chen YH,
    5. Wang WJ,
    6. Chiu YC,
    7. et al

    . In vitro evaluation of aerosol delivery by different nebulization modes in pediatric and adult mechanical ventilators. Respir Care 2014;59(10):1494-1500.

    OpenUrlAbstract/FREE Full Text
22. 22.↵
    1. Palmer LB,
    2. Smaldone GC,
    3. Simon S,
    4. O'Riordan T,
    5. Morra L

    . Tracheal aspirates in long-term mechanically ventilated patients. A human model of gram-negative infection and airway inflammation. Chest 1995;108(5):1326-1332.

    OpenUrlCrossRefPubMedWeb of Science
23. 23.↵
    1. Palmer LB,
    2. Smaldone GC,
    3. Simon SR,
    4. O'Riordan TG,
    5. Cuccia A

    . Aerosolized antibiotics in mechanically ventilated patients: delivery and response. Crit Care Med 1998;26(1):31-39.

    OpenUrlCrossRefPubMedWeb of Science
24. 24.↵
    1. Palmer LB,
    2. Smaldone GC

    . Reduction of bacterial resistance with inhaled antibiotics in the intensive care unit. Am J Respir Crit Care Med 2014;189(10):1225-1233.

    OpenUrlCrossRefPubMed
25. 25.↵
    1. Rau JL,
    2. Ari A,
    3. Restrepo RD

    . Performance comparison of nebulizer designs: constant-output, breath-enhanced, and dosimetric. Respir Care 2004;49(2):174-179.

    OpenUrlAbstract/FREE Full Text
26. 26.↵
    1. Rau JL

    . Design principles of liquid nebulization devices currently in use. Resp Care 2002;47(11):1257-1275; discussion 1275–1278.

    OpenUrl
27. 27.↵
    1. Palmer LB,
    2. Smaldone GC,
    3. Chen JJ,
    4. Baram D,
    5. Duan T,
    6. Monteforte M,
    7. et al

    . Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit. Crit Care Med 2008;36(7):2008-2013.

    OpenUrlCrossRefPubMedWeb of Science
28. 28.↵
    1. Luyt CE,
    2. Clavel M,
    3. Guntupalli K,
    4. Johannigman J,
    5. Kennedy JI,
    6. Wood C,
    7. et al

    . Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia. Crit Care 2009;13(6):R200.

    OpenUrlCrossRefPubMed
29. 29.↵
    1. Niederman MS,
    2. Chastre J,
    3. Corkery K,
    4. Fink JB,
    5. Luyt CE,
    6. Garcia MS

    . BAY41-6551 achieves bactericidal tracheal aspirate amikacin concentrations in mechanically ventilated patients with Gram-negative pneumonia. Intensive Care Med 2012;38(2):263-271.

    OpenUrlCrossRefPubMed
30. 30.↵
    1. Montgomery AB,
    2. Vallance S,
    3. Abuan T,
    4. Tservistas M,
    5. Davies A

    . A randomized double-blind placebo-controlled dose-escalation phase 1 study of aerosolized amikacin and fosfomycin delivered via the PARI investigational eFlow® inline nebulizer system in mechanically ventilated patients. J Aerosol Med Pulm Drug Deliv 2014;27(6):441-448.

    OpenUrlCrossRefPubMed
31. 31.↵
    1. Dhand R

    . Aerosol delivery during mechanical ventilation: from basic techniques to new devices. J Aerosol Med Pulm Drug Deliv 2008;21(1):45-60.

    OpenUrlCrossRefPubMedWeb of Science
32. 32.
    1. Solomita M,
    2. Daroowalla F,
    3. Leblanc DS,
    4. Smaldone GC

    . Y-piece temperature and humidification during mechanical ventilation. Respir Care 2009;54(4):480-486.

    OpenUrlAbstract/FREE Full Text
33. 33.↵
    1. Solomita M,
    2. Palmer LB,
    3. Daroowalla F,
    4. Liu J,
    5. Miller D,
    6. LeBlanc DS,
    7. Smaldone GC

    . Humidification and secretion volume in mechanically ventilated patients. Respir Care 2009;54(10):1329-1335.

    OpenUrlAbstract/FREE Full Text