Abstract
Despite its significant limitations, the PaO2/FIO2 remains the standard tool to classify disease severity in ARDS. Treatment decisions and research enrollment have depended on this parameter for over 50 years. In addition, several variables have been studied over the past few decades, incorporating other physiologic considerations such as ventilation efficiency, lung mechanics, and right-ventricular performance. This review describes the strengths and limitations of all relevant parameters, with the goal of helping us better understand disease severity and possible future treatment targets.
- ARDS
- classification
- risk stratification
- prognosis
- mortality
Footnotes
- Correspondence: Abhijit Duggal MD MPH MSc, Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195. E-mail: duggala2{at}ccf.org
Mr Chatburn discloses relationships with Jones & Bartlett Learning, Elsevier, U.S. patent number 8,550,077, IngMar Medical, Inovytec Medical Solutions, Vyaire Medical, Aires Medical, Ventis Medical, ProMedic, and AutoMedx. Dr Mireles-Cabodevila discloses relationships with IngMar Medical and Jones & Bartlett. The remaining authors have disclosed no conflicts of interest.
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