Asynchrony and DyspneaDiscussion

References

1. 1.↵
   1. Wunsch H,
   2. Linde-Zwirble WT,
   3. Angus DC,
   4. Hartman ME,
   5. Milbrandt EB,
   6. Kahn JM

   . The epidemiology of mechanical ventilation use in the United States. Crit Care Med 2010;38(12):1947-1953.

   OpenUrlPubMedWeb of Science
2. 2.↵
   1. Tobin MJ,
   2. Fahey PJ

   1. Tobin MJ,
   2. Fahey PJ

   . Management of the patient who is “fighting the ventilator.” In: Tobin MJ, Fahey PJ, editors. Principles and practice of mechanical ventilation. New York: McGraw Hill; 1994.
3. 3.↵
   1. Kallet RH

   . Patient-ventilator interaction during acute lung injury, and the role of spontaneous breathing. Part 2: airway pressure release ventilation. Respir Care 2011;56(2):190-203; discussion 203-206.

   OpenUrlAbstract/FREE Full Text
4. 4.
   1. Kallet RH

   . Patient-ventilator interaction during acute lung injury, and the role of spontaneous breathing. Part 1: respiratory muscle function during critical illness. Respir Care 2011;56(2):181-189.

   OpenUrlAbstract/FREE Full Text
5. 5.
   1. de Wit M

   . Monitoring of patient-ventilator interaction at the bedside. Respir Care 2011;56(1):61-72.

   OpenUrlAbstract/FREE Full Text
6. 6.↵
   1. Gentile MA

   . Cycling of the mechanical ventilator breath. Respir Care 2011;56(1):52-60.

   OpenUrlAbstract/FREE Full Text
7. 7.
   1. Sassoon CSH

   . Triggering of the ventilator in patient-ventilator interactions. Respir Care 2011;56(1):39-51.

   OpenUrlAbstract/FREE Full Text
8. 8.
   1. Epstein SK

   . How often does patient-ventilator asynchrony occur and what are the consequences? Respir Care 2011;56(1):25-38.

   OpenUrlAbstract/FREE Full Text
9. 9.
   1. Branson RD

   . Patient-ventilator interaction: the last 40 years. Respir Care 2011;56(1):15-24.

   OpenUrlAbstract/FREE Full Text
10. 10.↵
    1. Hess DR

    . Patient-ventilator interaction during noninvasive ventilation. Respir Care 2011;56(2):153-165; discussion 165-167.

    OpenUrlAbstract/FREE Full Text
11. 11.↵
    1. Marini JJ,
    2. Capps JS,
    3. Culver BH

    . The inspiratory work of breathing during assisted mechanical ventilation. Chest 1985;87(5):612-618.

    OpenUrlCrossRefPubMedWeb of Science
12. 12.↵
    1. Marini JJ,
    2. Smith TC,
    3. Lamb VJ

    . External work output and force generation during synchronized intermittent mechanical ventilation: effect of machine assistance on breathing effort. Am Rev Respir Dis 1988;138(5):1169-1179.

    OpenUrlPubMedWeb of Science
13. 13.↵
    1. Marini JJ,
    2. Rodriguez RM,
    3. Lamb V

    . Bedside estimation of the inspiratory work of breathing during mechanical ventilation. Chest 1986;89(1):56-63.

    OpenUrlCrossRefPubMed
14. 14.↵
    1. MacIntyre NR,
    2. McConnell R,
    3. Cheng KC,
    4. Sane A

    . Patient-ventilator flow dyssynchrony: flow-limited versus pressure-limited breaths. Crit Care Med 1997;25(10):1671-1677.

    OpenUrlCrossRefPubMedWeb of Science
15. 15.↵
    1. Tobin MJ,
    2. Jubran A,
    3. Laghi F

    . Patient-ventilator interaction. Am J Respir Crit Care Med 2001;163(5):1059-1063.

    OpenUrlCrossRefPubMedWeb of Science
16. 16.↵
    1. Laghi F,
    2. Karamchandani K,
    3. Tobin MJ

    . Influence of ventilator settings in determining respiratory frequency during mechanical ventilation. Am J Respir Crit Care Med 1999;160(5):1766-1770.

    OpenUrlPubMedWeb of Science
17. 17.↵
    1. Gurevitch MJ,
    2. Gelmont D

    . Importance of trigger sensitivity to ventilator response delay in advanced chronic obstructive pulmonary disease with respiratory failure. Crit Care Med 1989;17(4):354-359.

    OpenUrlPubMed
18. 18.↵
    1. Ashutosh K,
    2. Gilbert R,
    3. Auchincloss JH Jr.,
    4. Peppi D

    . Asynchronous breathing movements in patients with chronic obstructive pulmonary disease. Chest 1975;67(5):553-557.

    OpenUrlCrossRefPubMedWeb of Science
19. 19.↵
    1. Fabry B,
    2. Guttmann J,
    3. Eberhard L,
    4. Bauer T,
    5. Haberthur C,
    6. Wolff G

    . An analysis of desynchronization between the spontaneously breathing patient and ventilator during inspiratory pressure support. Chest 1995;107(5):1387-1394.

    OpenUrlCrossRefPubMedWeb of Science
20. 20.↵
    1. Chao DC,
    2. Scheinhorn DJ,
    3. Stearn-Hassenpflug M

    . Patient-ventilator trigger asynchrony in prolonged mechanical ventilation. Chest 1997;112(6):1592-1599.

    OpenUrlPubMed
21. 21.↵
    1. Thille AW,
    2. Rodriguez P,
    3. Cabello B,
    4. Lellouche F,
    5. Brochard L

    . Patient-ventilator asynchrony during assisted mechanical ventilation. Intensive Care Med 2006;32(10):1515-1522.

    OpenUrlCrossRefPubMedWeb of Science
22. 22.
    1. de Wit M,
    2. Pedram S,
    3. Best AM,
    4. Epstein SK

    . Observational study of patient-ventilator asynchrony and relationship to sedation level. J Crit Care 2009;24(1):74-80.

    OpenUrlPubMed
23. 23.↵
    1. de Wit M,
    2. Miller KB,
    3. Green DA,
    4. Ostman HE,
    5. Gennings C,
    6. Epstein SK

    . Ineffective triggering predicts increased duration of mechanical ventilation. Crit Care Med 2009;37(10):2740-2745.

    OpenUrlCrossRefPubMed
24. 24.↵
    1. Hill LL,
    2. Pearl RG

    . Flow triggering, pressure triggering, and autotriggering during mechanical ventilation. Crit Care Med 2000;28(2):579-581.

    OpenUrlCrossRefPubMedWeb of Science
25. 25.
    1. Imanaka H,
    2. Takeuchi M,
    3. Tachibana K,
    4. Nishimura M

    . Exhaled tidal volume overestimation in mechanically ventilated patients with large cardiogenic oscillation. Crit Care Med 2004;32(7):1546-1549.

    OpenUrlPubMed
26. 26.
    1. Arbour R

    . Cardiogenic oscillation and ventilator autotriggering in brain-dead patients: a case series. Am J Crit Care 2009;18(5):496, 488-495.

    OpenUrlAbstract/FREE Full Text
27. 27.
    1. Arbour RB

    . Confounding factors in brain death: cardiogenic ventilator autotriggering and implications for organ transplantation. Intensive Crit Care Nurs 2012;28(6):321-328.

    OpenUrlCrossRefPubMed
28. 28.
    1. Imanaka H,
    2. Nishimura M,
    3. Takeuchi M,
    4. Kimball WR,
    5. Yahagi N,
    6. Kumon K

    . Autotriggering caused by cardiogenic oscillation during flow-triggered mechanical ventilation. Crit Care Med 2000;28(2):402-407.

    OpenUrlCrossRefPubMedWeb of Science
29. 29.
    1. Sheikh E,
    2. Maguire DP,
    3. Gratch D

    . Autotriggering during pressure support ventilation due to cardiogenic oscillations. Anesth Analg 2009;109(2):470-472.

    OpenUrlCrossRefPubMed
30. 30.
    1. Dodd-Sullivan R,
    2. Quirin J,
    3. Newhart J

    . Ventilator autotriggering: a caution in brain death diagnosis. Prog Transplant 2011;21(2):152-155.

    OpenUrlPubMed
31. 31.
    1. Willatts SM,
    2. Drummond G

    . Brainstem death and ventilator trigger settings. Anaesthesia 2000;55(7):676-677.

    OpenUrlCrossRefPubMedWeb of Science
32. 32.↵
    1. McGee WT,
    2. Mailloux P

    . Ventilator autocycling and delayed recognition of brain death. Neurocrit Care 2011;14(2):267-271.

    OpenUrlPubMed
33. 33.↵
    1. France TE,
    2. Garnett AR,
    3. Grooms D

    . Inadvertent triggering of the ventilator caused by surgically placed pacer wires. Respir Care 2012;57(8):1334-1336.

    OpenUrlAbstract/FREE Full Text
34. 34.↵
    1. Carteaux G,
    2. Lyazidi A,
    3. Cordoba-Izquierdo A,
    4. Vignaux L,
    5. Jolliet P,
    6. Thille AW,
    7. et al

    . Patient-ventilator asynchrony during noninvasive ventilation: a bench and clinical study. Chest 2012;142(2):367-376.

    OpenUrlCrossRefPubMed
35. 35.↵
    1. Hess DR,
    2. Branson RD

    . Know your ventilator to beat the leak. Chest 2012;142(2):274-275.

    OpenUrlPubMed
36. 36.↵
    1. Prinianakis G,
    2. Kondili E,
    3. Georgopoulos D

    . Effects of the flow waveform method of triggering and cycling on patient-ventilator interaction during pressure support. Intensive Care Med 2003;29(11):1950-1959.

    OpenUrlCrossRefPubMed
37. 37.↵
    1. Kondili E,
    2. Prinianakis G,
    3. Georgopoulos D

    . Patient-ventilator interaction. Br J Anaesth 2003;91(1):106-119.

    OpenUrlFREE Full Text
38. 38.↵
    1. Vignaux L,
    2. Tassaux D,
    3. Carteaux G,
    4. Roeseler J,
    5. Piquilloud L,
    6. Brochard L,
    7. Jolliet P

    . Performance of noninvasive ventilation algorithms on ICU ventilators during pressure support: a clinical study. Intensive Care Med 2010;36(12):2053-2059.

    OpenUrlCrossRefPubMedWeb of Science
39. 39.↵
    1. Akoumianaki E,
    2. Lyazidi A,
    3. Rey N,
    4. Matamis D,
    5. Perez-Martinez N,
    6. Giraud R,
    7. et al

    . Mechanical ventilation-induced reverse triggered breaths: a frequently unrecognized form of neuro-mechanical coupling. Chest 2012 [Epub ahead of print] doi: 10.1378/chest.12-1817.
40. 40.↵
    1. Baconnier PF,
    2. Benchetrit G,
    3. Pachot P,
    4. Demongeot J

    . Entrainment of the respiratory rhythm: a new approach. J Theor Biol 1993;164(2):149-162.

    OpenUrlCrossRefPubMed
41. 41.
    1. Simon PM,
    2. Zurob AS,
    3. Wies WM,
    4. Leiter JC,
    5. Hubmayr RD

    . Entrainment of respiration in humans by periodic lung inflations. Effect of state and CO₂. Am J Respir Crit Care Med 1999;160(3):950-960.

    OpenUrlPubMedWeb of Science
42. 42.↵
    1. Pisarri TE,
    2. Yu J,
    3. Coleridge HM,
    4. Coleridge JC

    . Background activity in pulmonary vagal C-fibers and its effects on breathing. Respir Physiol 1986;64(1):29-43.

    OpenUrlCrossRefPubMedWeb of Science
43. 43.↵
    1. Sorichter S,
    2. Puschendorf B,
    3. Mair J

    . Skeletal muscle injury induced by eccentric muscle action: muscle proteins as markers of muscle fiber injury. Exerc Immunol Rev 1999;5(1):5-21.

    OpenUrlPubMedWeb of Science
44. 44.↵
    1. Leung P,
    2. Jubran A,
    3. Tobin MJ

    . Comparison of assisted ventilator modes on triggering, patient effort, and dyspnea. Am J Respir Crit Care Med 1997;155(6):1940-1948.

    OpenUrlCrossRefPubMedWeb of Science
45. 45.↵
    1. Jaber S,
    2. Delay JM,
    3. Matecki S,
    4. Sebbane M,
    5. Eledjam JJ,
    6. Brochard L

    . Volume-guaranteed pressure-support ventilation facing acute changes in ventilatory demand. Intensive Care Med 2005;31(9):1181-1188.

    OpenUrlPubMedWeb of Science
46. 46.↵
    1. Jaber S,
    2. Sebbane M,
    3. Verzilli D,
    4. Matecki S,
    5. Wysocki M,
    6. Eledjam JJ,
    7. Brochard L

    . Adaptive support and pressure support ventilation behavior in response to increased ventilatory demand. Anesthesiology 2009;110(3):620-627.

    OpenUrlPubMed
47. 47.↵
    1. Hess DR

    . Ventilator waveforms and the physiology of pressure support ventilation. Respir Care 2005;50(2):166-183; discussion 183-186.

    OpenUrlAbstract/FREE Full Text
48. 48.
    1. Murata S,
    2. Yokoyama K,
    3. Sakamoto Y,
    4. Yamashita K,
    5. Oto J,
    6. Imanaka H,
    7. Nishimura M

    . Effects of inspiratory rise time on triggering work load during pressure-support ventilation: a lung model study. Respir Care 2010;55(7):878-884.

    OpenUrlAbstract/FREE Full Text
49. 49.
    1. Yamada Y,
    2. Du HL

    . Analysis of the mechanisms of expiratory asynchrony in pressure support ventilation: a mathematical approach. J Appl Physiol 2000;88(6):2143-2150.

    OpenUrlAbstract/FREE Full Text
50. 50.
    1. Bonetto C,
    2. Caló MN,
    3. Delgado MO,
    4. Mancebo J

    . Modes of pressure delivery and patient-ventilator interaction. Respir Care Clin N Am 2005;11(2):247-263.

    OpenUrlPubMed
51. 51.
    1. Du HL,
    2. Amato MB,
    3. Yamada Y

    . Automation of expiratory trigger sensitivity in pressure support ventilation. Respir Care Clin N Am 2001;7(3):503-507.

    OpenUrlPubMed
52. 52.↵
    1. MacIntyre NR,
    2. Ho LI

    . Effects of initial flow rate and breath termination criteria on pressure support ventilation. Chest 1991;99(1):134-138.

    OpenUrlCrossRefPubMedWeb of Science
53. 53.↵
    1. Tokioka H,
    2. Tanaka T,
    3. Ishizu T,
    4. Fukushima T,
    5. Iwaki T,
    6. Nakamura Y,
    7. Kosogabe Y

    . The effect of breath termination criterion on breathing patterns and the work of breathing during pressure support ventilation. Anesth Analg 2001;92(1):161-165.

    OpenUrlPubMedWeb of Science
54. 54.
    1. Chiumello D,
    2. Polli F,
    3. Tallarini F,
    4. Chierichetti M,
    5. Motta G,
    6. Azzari S,
    7. et al

    . Effect of different cycling-off criteria and positive end-expiratory pressure during pressure support ventilation in patients with chronic obstructive pulmonary disease. Crit Care Med 2007;35(11):2547-2552.

    OpenUrlCrossRefPubMed
55. 55.↵
    1. Chiumello D,
    2. Pelosi P,
    3. Taccone P,
    4. Slutsky A,
    5. Gattinoni L

    . Effect of different inspiratory rise time and cycling off criteria during pressure support ventilation in patients recovering from acute lung injury. Crit Care Med 2003;31(11):2604-2610.

    OpenUrlCrossRefPubMedWeb of Science
56. 56.↵
    1. Kondili E,
    2. Xirouchaki N,
    3. Georgopoulos D

    . Modulation and treatment of patient-ventilator dyssynchrony. Curr Opin Crit Care 2007;13(1):84-89.

    OpenUrlPubMedWeb of Science
57. 57.
    1. Georgopoulos D,
    2. Prinianakis G,
    3. Kondili E

    . Bedside waveforms interpretation as a tool to identify patient-ventilator asynchronies. Intensive Care Med 2006;32(1):34-47.

    OpenUrlCrossRefPubMedWeb of Science
58. 58.↵
    1. Fernández-Pérez ER,
    2. Hubmayr RD

    . Interpretation of airway pressure waveforms. Intensive Care Med 2006;32(5):658-659.

    OpenUrlPubMed
59. 59.↵
    1. Parthasarathy S,
    2. Jubran A,
    3. Tobin MJ

    . Assessment of neural inspiratory time in ventilator-supported patients. Am J Respir Crit Care Med 2000;162(2 Pt 1):546-552.

    OpenUrlPubMedWeb of Science
60. 60.↵
    1. Parthasarathy S,
    2. Jubran A,
    3. Tobin MJ

    . Cycling of inspiratory and expiratory muscle groups with the ventilator in airflow limitation. Am J Respir Crit Care Med 1998;158(5 Pt 1):1471-1478.

    OpenUrlPubMedWeb of Science
61. 61.↵
    1. Younes M,
    2. Brochard L,
    3. Grasso S,
    4. Kun J,
    5. Mancebo J,
    6. Ranieri M,
    7. et al

    . A method for monitoring and improving patient: ventilator interaction. Intensive Care Med 2007;33(8):1337-1346.

    OpenUrlPubMed
62. 62.↵
    1. Robinson BRH,
    2. Blakeman TC,
    3. Toth P,
    4. Hanseman DJ,
    5. Mueller E,
    6. Branson RD

    . Patient ventilator asynchrony in a traumatically injured population. Respir Care 2013 [Epub ahead of print]
63. 63.↵
    1. Chen CW,
    2. Lin WC,
    3. Hsu CH,
    4. Cheng KS,
    5. Lo CS

    . Detecting ineffective triggering in the expiratory phase in mechanically ventilated patients based on airway flow and pressure deflection: feasibility of using a computer algorithm. Crit Care Med 2008;36(2):455-461.

    OpenUrlCrossRefPubMed
64. 64.↵
    1. Mulqueeny Q,
    2. Redmond SJ,
    3. Tassaux D,
    4. Vignaux L,
    5. et al

    . Automated detection of asynchrony in patient-ventilator interaction. Conf Proc IEEE Eng Med Biol Soc 2009;2009:5324-5327.

    OpenUrlPubMed
65. 65.↵
    1. Mulqueeny Q,
    2. Ceriana P,
    3. Carlucci A,
    4. Fanfulla F,
    5. Delmastro M,
    6. Nava S

    . Automatic detection of ineffective triggering and double triggering during mechanical ventilation. Intensive Care Med 2007;33(11):2014-2018.

    OpenUrlCrossRefPubMedWeb of Science
66. 66.↵
    1. Blanch L,
    2. Sales B,
    3. Montanya J,
    4. Lucangelo U,
    5. Garcia-Esquirol O,
    6. Villagra A,
    7. et al

    . Validation of the BetterCare system to detect ineffective efforts during expiration in mechanically ventilated patients: a pilot study. Intensive Care Med 2012;38(5):772-780. Erratum in: Intensive Care Med 2013;39(2):341.

    OpenUrlPubMed
67. 67.↵
    1. Cuvelier A,
    2. Achour L,
    3. Rabarimanantsoa H,
    4. Letellier C,
    5. Muir JF,
    6. Fauroux B

    . A noninvasive method to identify ineffective triggering in patients with noninvasive pressure support ventilation. Respiration 2010;80(3):198-206.

    OpenUrlPubMed
68. 68.↵
    1. Vignaux L,
    2. Vargas F,
    3. Roeseler J,
    4. Tassaux D,
    5. Thille AW,
    6. Kossowsky MP,
    7. et al

    . Patient-ventilator asynchrony during non-invasive ventilation for acute respiratory failure: a multicenter study. Intensive Care Med 2009;35(5):840-846.

    OpenUrlCrossRefPubMedWeb of Science
69. 69.
    1. Miyoshi E,
    2. Fujino Y,
    3. Uchiyama A,
    4. Mashimo T,
    5. Nishimura M

    . Effects of gas leak on triggering function, humidification, and inspiratory oxygen fraction during noninvasive positive airway pressure ventilation. Chest 2005;128(5):3691-3698.

    OpenUrlCrossRefPubMedWeb of Science
70. 70.
    1. Borel JC,
    2. Sabil A,
    3. Janssens JP,
    4. Couteau M,
    5. Boulon L,
    6. Levy P,
    7. et al

    . Intentional leaks in industrial masks have a significant impact on efficacy of bilevel noninvasive ventilation: a bench test study. Chest 2009;135(3):669-677.

    OpenUrlCrossRefPubMedWeb of Science
71. 71.
    1. Vignaux L,
    2. Tassaux D,
    3. Jolliet P

    . Performance of noninvasive ventilation modes on ICU ventilators during pressure support: a bench model study. Intensive Care Med 2007;33(8):1444-1451.

    OpenUrlCrossRefPubMedWeb of Science
72. 72.↵
    1. Ferreira JC,
    2. Chipman DW,
    3. Hill NS,
    4. Kacmarek RM

    . Bilevel vs ICU ventilators providing noninvasive ventilation: effect of system leaks: a COPD lung model comparison. Chest 2009;136(2):448-456.

    OpenUrlCrossRefPubMed
73. 73.↵
    1. Costa R,
    2. Navalesi P,
    3. Spinazzola G,
    4. Ferrone G,
    5. Pellegrini A,
    6. Cavaliere F,
    7. et al

    . Influence of ventilator settings on patient-ventilator synchrony during pressure support ventilation with different interfaces. Intensive Care Med 2010;36(8):1363-1370.

    OpenUrlCrossRefPubMedWeb of Science
74. 74.
    1. Branson RD,
    2. Gentile MA

    . Is humidification always necessary during noninvasive ventilation in the hospital? Respir Care 2010;55(2):209-216; discussion 216.

    OpenUrlAbstract/FREE Full Text
75. 75.
    1. Lellouche F,
    2. Maggiore SM,
    3. Deye N,
    4. Taillé S,
    5. Pigeot J,
    6. Harf A,
    7. et al

    . Effect of the humidification device on the work of breathing during noninvasive ventilation. Intensive Care Med 2002;28(11):1582-1589.

    OpenUrlCrossRefPubMedWeb of Science
76. 76.↵
    1. Jaber S,
    2. Chanques G,
    3. Matecki S,
    4. Ramonatxo M,
    5. Souche B,
    6. Perrigault PF,
    7. et al

    . Comparison of the effects of heat and moisture exchangers and heated humidifiers on ventilation and gas exchange during non-invasive ventilation. Intensive Care Med 2002;28(11):1590-1594.

    OpenUrlCrossRefPubMedWeb of Science
77. 77.↵
    1. Parthasarathy S,
    2. Tobin MJ

    . Effect of ventilator mode on sleep quality in critically ill patients. Am J Respir Crit Care Med 2002;1:166(11):1423-1429.

    OpenUrl
78. 78.↵
    1. Meza S,
    2. Mendez M,
    3. Ostrowski M,
    4. Younes M

    . Susceptibility to periodic breathing with assisted ventilation during sleep in normal subjects. J Appl Physiol 1998;85(5):1929-1940.

    OpenUrlAbstract/FREE Full Text
79. 79.
    1. Fanfulla F,
    2. Taurino AE,
    3. Lupo ND,
    4. Trentin R,
    5. D'Ambrosio C,
    6. Nava S

    . Effect of sleep on patient/ventilator asynchrony in patients undergoing chronic non-invasive mechanical ventilation. Respir Med 2007;101(8):1702-1707.

    OpenUrlCrossRefPubMedWeb of Science
80. 80.
    1. Bosma K,
    2. Ferreyra G,
    3. Ambrogio C,
    4. Pasero D,
    5. Mirabella L,
    6. Braghiroli A,
    7. et al

    . Patient-ventilator interaction and sleep in mechanically ventilated patients: pressure support versus proportional assist ventilation. Crit Care Med 2007;35(4):1048-1054.

    OpenUrlCrossRefPubMedWeb of Science
81. 81.↵
    1. Delisle S,
    2. Ouellet P,
    3. Bellemare P,
    4. Tétrault JP,
    5. Arsenault P

    . Sleep quality in mechanically ventilated patients: comparison between NAVA and PSV modes. Ann Intensive Care 2011;28;1(1):42.

    OpenUrl
82. 82.↵
    1. Córdoba-Izquierdo A,
    2. Drouot X,
    3. Thille AW,
    4. Galia F,
    5. Roche-Campo F,
    6. Schortgen F,
    7. et al

    . Sleep in hypercapnic critical care patients under noninvasive ventilation: conventional versus dedicated ventilators. Crit Care Med 2013;41(1):60-68.

    OpenUrlPubMed
83. 83.
    1. Toublanc B,
    2. Rose D,
    3. Glérant JC,
    4. Francois G,
    5. Mayeux I,
    6. Rodenstein D,
    7. Jounieaux V

    . Assist-control ventilation vs low levels of pressure support ventilation on sleep quality in intubated ICU patients. Intensive Care Med 2007;33(7):1148-1154.

    OpenUrlCrossRefPubMedWeb of Science
84. 84.↵
    1. Alexopoulou C,
    2. Kondili E,
    3. Vakouti E,
    4. Klimathianaki M,
    5. Prinianakis G,
    6. Georgopoulos D

    . Sleep during proportional-assist ventilation with load-adjustable gain factors in critically ill patients. Intensive Care Med 2007;33(7):1139-1147.

    OpenUrlCrossRefPubMedWeb of Science
85. 85.↵
    1. Anzueto A,
    2. Peters JI,
    3. Tobin MJ,
    4. de los Santos R,
    5. Seidenfeld JJ,
    6. Moore G,
    7. et al

    . Effects of prolonged controlled mechanical ventilation on diaphragmatic function in healthy adult baboons. Crit Care Med 1997;25(7):1187-1190.

    OpenUrlCrossRefPubMedWeb of Science
86. 86.
    1. Yang L,
    2. Luo J,
    3. Bourdon J,
    4. Lin MC,
    5. Gottfried SB,
    6. Petrof BJ

    . Controlled mechanical ventilation leads to remodeling of the rat diaphragm. Am J Respir Crit Care Med 2002;166(6):1135-1140.

    OpenUrlCrossRefPubMedWeb of Science
87. 87.
    1. Le Bourdelles G,
    2. Viires N,
    3. Boczkowski J,
    4. Seta N,
    5. Pavlovic D,
    6. Aubier M

    . Effects of mechanical ventilation on diaphragmatic contractile properties in rats. Am J Respir Crit Care Med 1994;149(10):1539-1544.

    OpenUrlPubMedWeb of Science
88. 88.↵
    1. Radell PJ,
    2. Remahl S,
    3. Nichols DG,
    4. Eriksson LI

    . Effects of prolonged mechanical ventilation and inactivity on piglet diaphragm function. Intensive Care Med 2002;28(3):358-364.

    OpenUrlCrossRefPubMedWeb of Science
89. 89.↵
    1. Vassilakopoulos T,
    2. Petrof BJ

    . Ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 2004;169(2):336-341.

    OpenUrlCrossRefPubMedWeb of Science
90. 90.↵
    1. Levine S,
    2. Nguyen T,
    3. Taylor N,
    4. Friscia ME,
    5. Budak MT,
    6. Rothenberg P,
    7. et al

    . Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 2008;358(13):1327-1335.

    OpenUrlCrossRefPubMedWeb of Science
91. 91.↵
    1. Levine S,
    2. Biswas C,
    3. Dierov J,
    4. Barsotti R,
    5. Shrager JB,
    6. Nguyen T,
    7. et al

    . Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse. Am J Respir Crit Care Med 2011;183(4):483-490.

    OpenUrlCrossRefPubMedWeb of Science
92. 92.↵
    1. Hermans G,
    2. Agten A,
    3. Testelmans D,
    4. Decramer M,
    5. Gayan-Ramirez G

    . Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study. Crit Care 2010;14(4):R127.

    OpenUrlCrossRefPubMed
93. 93.↵
    1. Jaber S,
    2. Petrof BJ,
    3. Jung B,
    4. Chanques G,
    5. Berthet JP,
    6. Rabuel C,
    7. et al

    . Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med 2011;183(3):364-371.

    OpenUrlCrossRefPubMedWeb of Science
94. 94.↵
    1. Hussain SN,
    2. Mofarrahi M,
    3. Sigala I,
    4. Kim HC,
    5. Vassilakopoulos T,
    6. Maltais F,
    7. et al

    . Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy. Am J Respir Crit Care Med 2010;182(11):1377-1386.

    OpenUrlCrossRefPubMedWeb of Science
95. 95.↵
    1. Papazian L,
    2. Forel JM,
    3. Gacouin A,
    4. Penot-Ragon C,
    5. Perrin G,
    6. Loundou A,
    7. et al

    . Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010;16:363(12):1107-1116.

    OpenUrl
96. 96.↵
    1. Tobin MJ

    . Dyspnea. Pathophysiologic basis, clinical presentation and management. Arch Intern Med 1990;150(8):1604-1613.

    OpenUrlCrossRefPubMedWeb of Science
97. 97.↵
    1. Shiber JR,
    2. Santana J

    . Dyspnea. Med Clin North Am 2006;90(3):453-479.

    OpenUrlPubMed
98. 98.↵
    1. Knebel AR,
    2. Janson-Bjerklie SL,
    3. Malley JD,
    4. Wilson AG,
    5. Marini JJ

    . Comparison of breathing comfort during weaning with two ventilatory modes. Am J Respir Crit Care Med 1994;149(1):14-18.

    OpenUrlCrossRefPubMedWeb of Science
99. 99.↵
    1. Schmidt M,
    2. Demoule A,
    3. Polito A,
    4. Porchet R,
    5. Aboab J,
    6. Siami S,
    7. et al

    . Dyspnea in mechanically ventilated critically ill patients. Crit Care Med 2011;39(9):2059-2065.

    OpenUrlCrossRefPubMedWeb of Science
100. 100.↵
     1. Perren A,
     2. Previsdomini M,
     3. Llamas M,
     4. Cerutti B,
     5. Györik S,
     6. Merlani G,
     7. Jolliet P

     . Patients' prediction of extubation success. Intensive Care Med 2010;36(12):2045-2052.

     OpenUrlCrossRefPubMedWeb of Science